publication . Other literature type . Article . 2012

Docosahexaenoic Acid for Reading, Cognition and Behavior in Children Aged 7–9 Years: A Randomized, Controlled Trial (The DOLAB Study)

Richardson, Alexandra J.; Burton, Jennifer R.; Sewell, Richard P.; Spreckelsen, Thees F.; Montgomery, Paul;
  • Published: 06 Sep 2012
  • Publisher: Public Library of Science (PLoS)
Abstract
Background: \ud Omega-3 fatty acids are dietary essentials, and the current low intakes in most modern developed countries are believed to contribute to a wide variety of physical and mental health problems. Evidence from clinical trials indicates that dietary supplementation with long-chain omega-3 may improve child behavior and learning, although most previous trials have involved children with neurodevelopmental disorders such as attention-deficit/hyperactivity disorder (ADHD) or developmental coordination disorder (DCD). Here we investigated whether such benefits might extend to the general child population.\ud \ud Objectives: \ud To determine the effects of...
Subjects
free text keywords: Research Article, Biology, Biochemistry, Lipids, Fatty Acids, Neuroscience, Cognitive Neuroscience, Working Memory, Medicine, Clinical Research Design, Clinical Trials, Complementary and Alternative Medicine, Drugs and Devices, Behavioral Pharmacology, Epidemiology, Pediatric Epidemiology, Mental Health, Psychiatry, Child Psychiatry, Psychology, Behavior, Attention (Behavior), Cognitive Psychology, Learning, Neurology, Developmental and Pediatric Neurology, Non-Clinical Medicine, Health Care Policy, Child and Adolescent Health Policy, Nutrition, Malnutrition, Micronutrient Deficiencies, Pediatrics, Child Development, Public Health, Behavioral and Social Aspects of Health, Child Health, Social and Behavioral Sciences, Science Education, Literacy, R, Science, Q, General Biochemistry, Genetics and Molecular Biology, General Agricultural and Biological Sciences, General Medicine, Developed country, Cognition, Population, education.field_of_study, education, Clinical trial, medicine.medical_specialty, Placebo, Randomized controlled trial, law.invention, law, Clinical psychology
Related Organizations
32 references, page 1 of 3

1 Simopoulos A (2002) The importance of the ratio of omega-6/omega-3 essential fatty acids. Biomed Pharmacother 56: 365–379.12442909 [PubMed]

2 Brenna JT, Salem N, Sinclair AJ, Cunnane SC (2009) Alpha-Linolenic acid supplementation and conversion to n-3 long-chain polyunsaturated fatty acids in humans. Prostaglandins Leukot Essent Fatty Acids 80: 85–91.19269799 [PubMed]

3 Schuchardt JP, Huss M, Stauss-Grabo M, Hahn A (2010) Significance of long-chain polyunsaturated fatty acids (PUFAs) for the development and behaviour of children. Eur J Pediatr 169: 149–164.19672626 [PubMed]

4 Ryan AS, Astwood JD, Gautier S, Kuratko CN, Nelson EB, et al (2010) Effects of long-chain polyunsaturated fatty acid supplementation on neurodevelopment in childhood: a review of human studies. Prostaglandins Leukot Essent Fatty Acids 82: 305–314.20188533 [OpenAIRE] [PubMed]

5 Richardson AJ (2006) Omega-3 fatty acids in ADHD and related neurodevelopmental disorders. Int Rev Psychiatry 18: 155–172.16777670 [PubMed]

6 Bloch MH, Qawasmi A (2011) Omega-3 fatty acid supplementation for the treatment of children with attention-deficit/hyperactivity disorder symptomatology: systematic review and meta-analysis. J Am Acad Child Adolesc Psychiatry 50: 991–1000.21961774 [OpenAIRE] [PubMed]

7 Richardson AJ, Montgomery P (2005) The Oxford-Durham study: a randomized, controlled trial of dietary supplementation with fatty acids in children with developmental coordination disorder. Pediatrics 115: 1360–1366.15867048 [OpenAIRE] [PubMed]

8 Ells L, Hillier F, Summerbell C (2006) A systematic review of the effect of nutrition, diet and dietary change on learning, education and performance of children of relevance to UK schools. Middlesborough: University of Teeside.

9 Department of Education website. Available: www.education.gov.uk/rsgateway/DB/STR/d001032/osr20-2011.pdf. Accessed 2012 Jul 17.

10 Her Majesty's Stationery Office website. Available: www.hm-treasury.gov.uk/d/leitch_finalreport051206.pdf. Accessed 2012 Jul 17.

11 Heckman J, Masterov D (2007) The Productivity Argument for Investing in Young Children. Appl Econ Perspect Pol 29: 446–493. [OpenAIRE]

12 Gathercole SE, Alloway TP, Willis C, Adams A-M (2006) Working memory in children with reading disabilities. J Exp Child Psychol 93: 265–281.16293261 [PubMed]

13 Nevo E, Breznitz Z (2011) Assessment of working memory components at 6 years of age as predictors of reading achievements a year later. J Exp Child Psychol 109: 73–90.21115182 [OpenAIRE] [PubMed]

14 Collishaw S, Gardner F, Maughan B, Scott J, Pickles A (2012) Do historical changes in parent-child relationships explain increases in youth conduct problems? J Abnorm Child Psychol 40: 119–132.21789521 [PubMed]

15 Elliott B, Smith P, McCulloch K (1997) British Ability Scales Second Edition (BAS II): technical manual. Windsor: NFER-Nelson.

32 references, page 1 of 3
Abstract
Background: \ud Omega-3 fatty acids are dietary essentials, and the current low intakes in most modern developed countries are believed to contribute to a wide variety of physical and mental health problems. Evidence from clinical trials indicates that dietary supplementation with long-chain omega-3 may improve child behavior and learning, although most previous trials have involved children with neurodevelopmental disorders such as attention-deficit/hyperactivity disorder (ADHD) or developmental coordination disorder (DCD). Here we investigated whether such benefits might extend to the general child population.\ud \ud Objectives: \ud To determine the effects of...
Subjects
free text keywords: Research Article, Biology, Biochemistry, Lipids, Fatty Acids, Neuroscience, Cognitive Neuroscience, Working Memory, Medicine, Clinical Research Design, Clinical Trials, Complementary and Alternative Medicine, Drugs and Devices, Behavioral Pharmacology, Epidemiology, Pediatric Epidemiology, Mental Health, Psychiatry, Child Psychiatry, Psychology, Behavior, Attention (Behavior), Cognitive Psychology, Learning, Neurology, Developmental and Pediatric Neurology, Non-Clinical Medicine, Health Care Policy, Child and Adolescent Health Policy, Nutrition, Malnutrition, Micronutrient Deficiencies, Pediatrics, Child Development, Public Health, Behavioral and Social Aspects of Health, Child Health, Social and Behavioral Sciences, Science Education, Literacy, R, Science, Q, General Biochemistry, Genetics and Molecular Biology, General Agricultural and Biological Sciences, General Medicine, Developed country, Cognition, Population, education.field_of_study, education, Clinical trial, medicine.medical_specialty, Placebo, Randomized controlled trial, law.invention, law, Clinical psychology
Related Organizations
32 references, page 1 of 3

1 Simopoulos A (2002) The importance of the ratio of omega-6/omega-3 essential fatty acids. Biomed Pharmacother 56: 365–379.12442909 [PubMed]

2 Brenna JT, Salem N, Sinclair AJ, Cunnane SC (2009) Alpha-Linolenic acid supplementation and conversion to n-3 long-chain polyunsaturated fatty acids in humans. Prostaglandins Leukot Essent Fatty Acids 80: 85–91.19269799 [PubMed]

3 Schuchardt JP, Huss M, Stauss-Grabo M, Hahn A (2010) Significance of long-chain polyunsaturated fatty acids (PUFAs) for the development and behaviour of children. Eur J Pediatr 169: 149–164.19672626 [PubMed]

4 Ryan AS, Astwood JD, Gautier S, Kuratko CN, Nelson EB, et al (2010) Effects of long-chain polyunsaturated fatty acid supplementation on neurodevelopment in childhood: a review of human studies. Prostaglandins Leukot Essent Fatty Acids 82: 305–314.20188533 [OpenAIRE] [PubMed]

5 Richardson AJ (2006) Omega-3 fatty acids in ADHD and related neurodevelopmental disorders. Int Rev Psychiatry 18: 155–172.16777670 [PubMed]

6 Bloch MH, Qawasmi A (2011) Omega-3 fatty acid supplementation for the treatment of children with attention-deficit/hyperactivity disorder symptomatology: systematic review and meta-analysis. J Am Acad Child Adolesc Psychiatry 50: 991–1000.21961774 [OpenAIRE] [PubMed]

7 Richardson AJ, Montgomery P (2005) The Oxford-Durham study: a randomized, controlled trial of dietary supplementation with fatty acids in children with developmental coordination disorder. Pediatrics 115: 1360–1366.15867048 [OpenAIRE] [PubMed]

8 Ells L, Hillier F, Summerbell C (2006) A systematic review of the effect of nutrition, diet and dietary change on learning, education and performance of children of relevance to UK schools. Middlesborough: University of Teeside.

9 Department of Education website. Available: www.education.gov.uk/rsgateway/DB/STR/d001032/osr20-2011.pdf. Accessed 2012 Jul 17.

10 Her Majesty's Stationery Office website. Available: www.hm-treasury.gov.uk/d/leitch_finalreport051206.pdf. Accessed 2012 Jul 17.

11 Heckman J, Masterov D (2007) The Productivity Argument for Investing in Young Children. Appl Econ Perspect Pol 29: 446–493. [OpenAIRE]

12 Gathercole SE, Alloway TP, Willis C, Adams A-M (2006) Working memory in children with reading disabilities. J Exp Child Psychol 93: 265–281.16293261 [PubMed]

13 Nevo E, Breznitz Z (2011) Assessment of working memory components at 6 years of age as predictors of reading achievements a year later. J Exp Child Psychol 109: 73–90.21115182 [OpenAIRE] [PubMed]

14 Collishaw S, Gardner F, Maughan B, Scott J, Pickles A (2012) Do historical changes in parent-child relationships explain increases in youth conduct problems? J Abnorm Child Psychol 40: 119–132.21789521 [PubMed]

15 Elliott B, Smith P, McCulloch K (1997) British Ability Scales Second Edition (BAS II): technical manual. Windsor: NFER-Nelson.

32 references, page 1 of 3
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