publication . Other literature type . Article . 2005

Passive All-Optical Force Clamp for High-Resolution Laser Trapping

Steven M. Block; William J. Greenleaf; Michael T. Woodside; Elio A. Abbondanzieri;
Open Access English
  • Published: 08 Nov 2005
Optical traps are useful for studying the effects of forces on single molecules. Feedback-based force clamps are often used to maintain a constant load, but the response time of the feedback limits bandwidth and can introduce instability. We developed a novel force clamp that operates without feedback, taking advantage of the anharmonic region of the trapping potential where the differential stiffness vanishes. We demonstrate the utility of such a force clamp by measuring the unfolding of DNA hairpins and the effect of trap stiffness on opening distance and transition rates.
arXiv: Quantitative Biology::Biomolecules
free text keywords: Article, General Physics and Astronomy, Optical tweezers, Trapping, Anharmonicity, Materials science, Nanotechnology, Instability, Response time, Laser, law.invention, law, Clamp, Mechanics, Stiffness, medicine.symptom, medicine
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