publication . Other literature type . Article . 2004

Molecular origins of rapid and continuous morphological evolution

Fondon, John W.; Garner, Harold R.;
Open Access
  • Published: 13 Dec 2004
  • Publisher: Proceedings of the National Academy of Sciences
Mutations in cis-regulatory sequences have been implicated as being the predominant source of variation in morphological evolution. We offer a hypothesis that gene-associated tandem repeat expansions and contractions are a major source of phenotypic variation in evolution. Here, we describe a comparative genomic study of repetitive elements in developmental genes of 92 breeds of dogs. We find evidence for selection for divergence at coding repeat loci in the form of both elevated purity and extensive length polymorphism among different breeds. Variations in the number of repeats in the coding regions of the Alx-4 (aristaless-like 4) and Runx-2 (runt-related tran...
free text keywords: Biological Sciences
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