publication . Article . Other literature type . 2005

The Transcriptional Landscape of the Mammalian Genome

Martin Madera; Hiroaki Kitano; Ken Yagi; Yasushi Okazaki; Luca Sessa; N. Maeda; Masaaki Katoh; S. P. T. Krishnan; S. Miyake; Claes Wahlestedt; ...
  • Published: 02 Sep 2005 Journal: Science, volume 309, pages 1,559-1,563 (issn: 0036-8075, eissn: 1095-9203, Copyright policy)
  • Publisher: American Association for the Advancement of Science (AAAS)
This study describes comprehensive polling of transcription start and termination sites and analysis of previously unidentified full-length complementary DNAs derived from the mouse genome. We identify the 5' and 3' boundaries of 181,047 transcripts with extensive variation in transcripts arising from alternative promoter usage, splicing, and polyadenylation. There are 16,247 new mouse protein-coding transcripts, including 5154 encoding previously unidentified proteins. Genomic mapping of the transcriptome reveals transcriptional forests, with overlapping transcription on both strands, separated by deserts in which few transcripts are observed. The data provide ...
free text keywords: Multidisciplinary, RNA splicing, Genomics, Transcriptome, Polyadenylation, Transcription (biology), Three prime untranslated region, Genetics, Genome, Biology, Transcriptional regulation
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