publication . Article . Other literature type . 2006

Local force and geometry sensing regulate cell functions

Viola Vogel; Michael P. Sheetz;
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  • Published: 22 Feb 2006 Journal: Nature Reviews Molecular Cell Biology, volume 7, pages 265-275 (issn: 1471-0072, eissn: 1471-0080, Copyright policy)
  • Publisher: Springer Science and Business Media LLC
Abstract
The shapes of eukaryotic cells and ultimately the organisms that they form are defined by cycles of mechanosensing, mechanotransduction and mechanoresponse. Local sensing of force or geometry is transduced into biochemical signals that result in cell responses even for complex mechanical parameters such as substrate rigidity and cell-level form. These responses regulate cell growth, differentiation, shape changes and cell death. Recent tissue scaffolds that have been engineered at the micro- and nanoscale level now enable better dissection of the mechanosensing, transduction and response mechanisms.
Subjects
free text keywords: Mechanotransduction, Programmed cell death, Transduction (genetics), Cell physiology, Traction force microscopy, Cell functions, Biology, Cell biology, Cell growth, Geometry, Tissue scaffolds
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