publication . Article . Other literature type . 2005

Neurofilament phosphoforms: Surrogate markers for axonal injury, degeneration and loss

Axel Petzold;
Open Access
  • Published: 15 Jun 2005
  • Publisher: ELSEVIER SCIENCE BV
  • Country: United Kingdom
Abstract
This review on the role of neurofilaments as surrogate markers for axonal degeneration in neurological diseases provides a brief background to protein synthesis, assembly, function and degeneration. Methodological techniques for quantification are described and a protein nomenclature is proposed. The relevance for recognising antineurofilament autoantibodies is noted. Pathological implications are discussed in view of immunocytochemical, cell-culture and genetic findings. With reference to the present symposium on multiple sclerosis, the current literature on body fluid levels of neurofilaments in demyelinating disease is summarised. (c) 2005 Elsevier B.V All ri...
Subjects
free text keywords: axonal degeneration, blood, cerebrospinal fluid, intermediate filaments, neurofilament, nfH, nfL, NfM, nomenclature, phosphorylation, surrogate marker, biomarker, AMYOTROPHIC-LATERAL-SCLEROSIS, MOTOR-NEURON DISEASE, MARIE-TOOTH-DISEASE, SUBUNIT NF-H, GLYCOGEN-SYNTHASE KINASE-3, DEPENDENT PROTEIN-KINASE, MULTIPLE-SCLEROSIS, INTERMEDIATE-FILAMENTS, ALZHEIMERS-DISEASE, NEUROFIBRILLARY TANGLES, Neurology, Clinical Neurology, Multiple sclerosis, medicine.disease, medicine, Demyelinating disease, Pathology, medicine.medical_specialty, Amyotrophic lateral sclerosis, Biomarker (medicine), Neuroscience, Autoantibody, business.industry, business, Pathological, Neurofilament, Surrogate endpoint
Related Organizations

[1] [2] [3] [4] [5] [6] [7] [8] [9] E Fuchs and DW Cleveland. A structural scaffolding of intermediate filaments in health and disease. Science, 279:514-519, 1998.

GM Cooper, editor. The Cell - A Molecular Approach. Sunderland (MA): Sinauer Associates, Inc., 2000.

MK Lee and DW Cleveland. Neuronal intermediate filaments. Ann Rev Neurosci, 19:187-217, 1996.

JF Lees, PS Shneidman, SF Skuntz, MJ Carden, and RA Lazzarini. The structure and organization of the human heavy neurofilament subunit (NFH) and the gene encoding it. EMBO1988, 7:1947-1955, 1988.

EMBO J, 2:1295-1502, 1983.

RK Sihag and RA Nixon. In vivo phosphorylation of distinct domains of the 70- kilodalton neurofilament subunit involves different protein- kinases. J Biol Chem, 264:457-464, 1989.

SR Gill, PC Wong, MJ Monteiro, and DW Cleveland. Assembly properties of dominant and recessive mutations in the small mouse neurofilament (NfL) subunit. J Cell Biology, 111:2005-2019, 1990.

S Hisanaga, Y Gonda, M Inagaki, A Ikai, and N Hirokawa. Effects of phosphorylation of the neurofilament L-protein on filamentous structures. Cell Regulation, 1:237-248, 1990. [OpenAIRE]

Effect of phosphorylation on 68 kda neurofilament subunit protein assembly by the cyclic-amp dependent protein-kinase in vitro. Biochem Biophys Res Comm, 169:744-750, 1990.

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