publication . Article . Other literature type . 2005

Neurofilament phosphoforms: Surrogate markers for axonal injury, degeneration and loss

Axel Petzold;
Open Access
  • Published: 15 Jun 2005
  • Country: United Kingdom
This review on the role of neurofilaments as surrogate markers for axonal degeneration in neurological diseases provides a brief background to protein synthesis, assembly, function and degeneration. Methodological techniques for quantification are described and a protein nomenclature is proposed. The relevance for recognising antineurofilament autoantibodies is noted. Pathological implications are discussed in view of immunocytochemical, cell-culture and genetic findings. With reference to the present symposium on multiple sclerosis, the current literature on body fluid levels of neurofilaments in demyelinating disease is summarised. (c) 2005 Elsevier B.V All ri...
free text keywords: axonal degeneration, blood, cerebrospinal fluid, intermediate filaments, neurofilament, nfH, nfL, NfM, nomenclature, phosphorylation, surrogate marker, biomarker, AMYOTROPHIC-LATERAL-SCLEROSIS, MOTOR-NEURON DISEASE, MARIE-TOOTH-DISEASE, SUBUNIT NF-H, GLYCOGEN-SYNTHASE KINASE-3, DEPENDENT PROTEIN-KINASE, MULTIPLE-SCLEROSIS, INTERMEDIATE-FILAMENTS, ALZHEIMERS-DISEASE, NEUROFIBRILLARY TANGLES, Neurology, Clinical Neurology, Multiple sclerosis, medicine.disease, medicine, Demyelinating disease, Pathology, medicine.medical_specialty, Amyotrophic lateral sclerosis, Biomarker (medicine), Neuroscience, Autoantibody, business.industry, business, Pathological, Neurofilament, Surrogate endpoint
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