research data . Dataset . 2016

A genetic variant of the NTCP gene is associated with HBV infection status in a Chinese population

Jingmin Yang; Yang, Yuan; Mingying Xia; Lianghui Wang; Weiping Zhou; Yajun Yang; Yueming Jiang; Hongyang Wang; Qian, Ji; Jin, Li; ...
  • Published: 15 Dec 2016
  • Publisher: Figshare
Abstract
Abstract Background To investigate whether genetic variants of the HBV receptor gene NTCP are associated with HBV infection in the Han Chinese population. Methods We sequenced the entire 23 kb NTCP gene from 111 HBeAg-positive HBsAg carriers (PSE group), 110 HBeAg-negative HBsAg carriers (PS group), and 110 control subjects. Then, we performed association analyses of suggestively significant SNPs with HBV infection in 1075 controls, 1936 PSs and 639 PSEs. Results In total, 109 rare variants (74 novel) and 38 single nucleotide polymorphisms (SNPs, one novel) were screened. Of the seven non-synonymous rare variants, six were singletons and one was a double hit. Al...
Subjects
Medical Subject Headings: digestive system diseases
free text keywords: Medicine, Genetics, FOS: Biological sciences, Molecular Biology, Biotechnology, 39999 Chemical Sciences not elsewhere classified, FOS: Chemical sciences, 69999 Biological Sciences not elsewhere classified, Cancer, 111714 Mental Health, FOS: Health sciences, 110309 Infectious Diseases, 60506 Virology, Mental Health, Infectious Diseases, Virology
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Dataset . 2016
Provider: Datacite
figshare
Dataset . 2016
Provider: Datacite
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