publication . Article . Other literature type . 2005

Using voxel-based morphometry to map the structural changes associated with rapid conversion in MCI: a longitudinal MRI study.

jean-claude baron; Béatrice Desgranges; Francis Eustache;
  • Published: 01 Oct 2005 Journal: NeuroImage, volume 27, pages 934-946 (issn: 1053-8119, Copyright policy)
  • Publisher: Elsevier BV
Capturing the dynamics of gray matter (GM) atrophy in relation to the conversion from mild cognitive impairment (MCI) to clinically probable Alzheimer's disease (AD) would be of considerable interest. In this prospective study we have used a novel longitudinal voxel-based method to map the progression of GM loss in MCI patients over time and compared converters to non-converters. Eighteen amnestic MCI patients were followed-up for a predefined fixed period of 18 months and conversion was judged according to NINCDS-ADRDA criteria for probable AD. Each patient underwent a high-resolution T1-weighted volume MRI scan both at entry in the study and 18 months later. W...
free text keywords: Cognitive Neuroscience, Neurology
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