publication . Article . Other literature type . 1988

DNA stem-loop structures in oligopurine-oligopyrimidine triplexes.

Harvey, S C; Luo, J; Lavery, R;
Open Access English
  • Published: 23 Dec 1988
  • Publisher: HAL CCSD
International audience; Closed circular DNA containing polypurine-polypyrimidine sequences can adopt a triple helical stem-loop structure under supercoiling pressure. We describe an automated procedure for building model loops and its application to the investigation of the polypyrimidine loop at the end of such a triple helical stem. All possible combinations of 3'-stacked and 5'-stacked structures have been examined for loops containing three, four, five, and six nucleotides. The lowest energy conformation is a four-membered loop with all bases stacked on the strand at the 3' end of the loop. The model predicts that sequences (GA)n, (GGGA)n and (GAAA)n should ...
free text keywords: [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology
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Other literature type . 1988
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