publication . Article . Other literature type . 1988

DNA stem-loop structures in oligopurine-oligopyrimidine triplexes.

Harvey, S C; Luo, J; Lavery, R;
Open Access English
  • Published: 23 Dec 1988
  • Publisher: HAL CCSD
Abstract
International audience; Closed circular DNA containing polypurine-polypyrimidine sequences can adopt a triple helical stem-loop structure under supercoiling pressure. We describe an automated procedure for building model loops and its application to the investigation of the polypyrimidine loop at the end of such a triple helical stem. All possible combinations of 3'-stacked and 5'-stacked structures have been examined for loops containing three, four, five, and six nucleotides. The lowest energy conformation is a four-membered loop with all bases stacked on the strand at the 3' end of the loop. The model predicts that sequences (GA)n, (GGGA)n and (GAAA)n should ...
Subjects
free text keywords: [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology
Download fromView all 2 versions
Europe PubMed Central
Other literature type . 1988
Powered by OpenAIRE Research Graph
Any information missing or wrong?Report an Issue