publication . Other literature type . Article . 2001

Insulin signalling and the regulation of glucose and lipid metabolism

Alan R. Saltiel; C. Ronald Kahn;
  • Published: 01 Dec 2001
  • Publisher: Springer Science and Business Media LLC
Abstract
The epidemic of type 2 diabetes and impaired glucose tolerance is one of the main causes of morbidity and mortality worldwide. In both disorders, tissues such as muscle, fat and liver become less responsive or resistant to insulin. This state is also linked to other common health problems, such as obesity, polycystic ovarian disease, hyperlipidaemia, hypertension and atherosclerosis. The pathophysiology of insulin resistance involves a complex network of signalling pathways, activated by the insulin receptor, which regulates intermediary metabolism and its organization in cells. But recent studies have shown that numerous other hormones and signalling events att...
Subjects
free text keywords: Hormone, Impaired glucose tolerance, medicine.disease, medicine, Polycystic ovarian disease, Type 2 diabetes, Lipid metabolism, Biology, Insulin, medicine.medical_treatment, Insulin receptor, biology.protein, Internal medicine, medicine.medical_specialty, Insulin resistance, Endocrinology
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http://dx.doi.org/10.1038/4147...
Other literature type . 2001
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publication . Other literature type . Article . 2001

Insulin signalling and the regulation of glucose and lipid metabolism

Alan R. Saltiel; C. Ronald Kahn;