publication . Article . 2017

Meta-analysis of genome-wide SNP- and pathway-based associations for facets of neuroticism

Kim, Song E; Kim, Han-Na; Yun, Yeo-Jun; Heo, Seong Gu; Cho, Juhee; Kwon, Min-Jung; Chang, Yoosoo; Ryu, Seungho; Shin, Hocheol; Shin, Chol; ...
Open Access
  • Published: 15 Jun 2017 Journal: Journal of Human Genetics, volume 62, pages 903-909 (issn: 1434-5161, eissn: 1435-232X, Copyright policy)
  • Publisher: Springer Science and Business Media LLC
Abstract
Neuroticism is a heritable personality trait that is comprised of distinct sub-factors, or facets. Sub-factors of neuroticism are linked to different emotional states or psychiatric symptoms and studying the genetic variants associated with these facets may help reveal the biological mechanisms underlying psychiatric disorders. In the present study, a meta-analysis of genome-wide association studies for six facets of neuroticism was performed in 5584 participants from three cohorts. Additionally, a Gene Set Enrichment Analysis was conducted to find biological pathways associated with each facet. Six neuroticism facets (N1: anxiety, N2: angry hostility, N3: depre...
Subjects
Medical Subject Headings: mental disorders
free text keywords: Genetics(clinical), Genetics, Hostility, medicine.symptom, medicine, Anxiety, Revised NEO Personality Inventory, Personality, media_common.quotation_subject, media_common, Impulsivity, Genetic association, Neuroticism, Genome-wide association study, Biology, Original Article
Related Organizations
54 references, page 1 of 4

Reynaud, E., El Khoury-Malhame, M., Rossier, J., Blin, O. & Khalfa, S. Neuroticism modifies psychophysiological responses to fearful films. PLoS ONE 7, e32413 (2012).22479326 [OpenAIRE] [PubMed]

Ormel, J., Jeronimus, B. F., Kotov, R., Riese, H., Bos, E. H., Hankin, B. et al. Neuroticism and common mental disorders: meaning and utility of a complex relationship. Clin. Psychol. Rev. 33, 686–697 (2013).23702592 [OpenAIRE] [PubMed]

Brown, T. A. & Rosellini, A. J. The direct and interactive effects of neuroticism and life stress on the severity and longitudinal course of depressive symptoms. J. Abnormal. Psychol. 120, 844–856 (2011).

Costa, P. & McCrae, R. Revised NEO P ersonality Inventory (NEO-PI-R) and NEO Five-Factor Inventory (NEO-FFI) Professional Manual, Psychological Assessment Resources, Odessa, FL, USA, (1992).

Shifman, S., Bhomra, A., Smiley, S., Wray, N. R., James, M. R., Martin, N. G. et al. A whole genome association study of neuroticism using DNA pooling. Mol. Psychiatry 13, 302–312 (2008).17667963 [OpenAIRE] [PubMed]

Terracciano, A., Sanna, S., Uda, M., Deiana, B., Usala, G., Busonero, F. et al. Genome-wide association scan for five major dimensions of personality. Mol. Psychiatry 15, 647–656 (2010).18957941 [OpenAIRE] [PubMed]

Calboli, F. C., Tozzi, F., Galwey, N. W., Antoniades, A., Mooser, V., Preisig, M. et al. A genome-wide association study of neuroticism in a population-based sample. PLoS ONE 5, e11504 (2010).20634892 [OpenAIRE] [PubMed]

Kim, H. N., Roh, S. J., Sung, Y. A., Chung, H. W., Lee, J. Y., Cho, J. et al. Genome-wide association study of the five-factor model of personality in young Korean women. J. Hum. Genet. 58, 667–674 (2013).23903073 [PubMed]

Terraccian o, A., Tanaka, T., Sutin, A. R., Sanna, S., Deiana, B., Lai, S. et al. Genome-wide association scan of trait depression. Biol. Psychiatry 68, 811–817 (2010).20800221 [OpenAIRE] [PubMed]

Smith, D. J., Escott-Price, V., Davies, G., Bailey, M. E., Colodro-Conde, L., Ward, J. et al. Genome-wide analysis of over 106 000 individuals identifies 9 neuroticism-associated loci. Mol. Psychiatry 21, 1644 (2016).27620839 [PubMed]

Okbay, A., Baselmans, B. M., De Neve, J. E., Turley, P., Nivard, M. G., Fontana, M. A. et al. Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses. Nat. Genet. 48, 624–633 (2016).27089181 [OpenAIRE] [PubMed]

de Moor, M. H., van den Berg, S. M., Verweij, K. J., Krueger, R. F., Luciano, M., Arias Vasquez, A. et al. Meta-analysis of genome-wide association studies for neuroticism, and the polygenic association with major depressive disorder. JAMA Psychiatry 72, 642–650 (2015).25993607 [OpenAIRE] [PubMed]

Jang, K. L., McCrae, R. R., Angleitner, A., Riemann, R. & Livesley, W. J. Heritability of facet-level traits in a cross-cultural twin sample: support for a hierarchical model of personality. J. Personal. Soc. Psychol. 74, 1556–1565 (1998).

Hirschhorn, J. N. & Daly, M. J. Genome-wide association studies for common diseases and complex traits. Nat. Rev. Genet. 6, 95–108 (2005).15716906 [PubMed]

Segre, A. V., Groop, L., Mootha, V. K., Daly, M. J. & Altshuler, D. Common inherited variation in mitochondrial genes is not enriched for associations with type 2 diabetes or related glycemic traits. PLoS Genet 6, e1001058 (2010).20714348 [OpenAIRE] [PubMed]

54 references, page 1 of 4
Abstract
Neuroticism is a heritable personality trait that is comprised of distinct sub-factors, or facets. Sub-factors of neuroticism are linked to different emotional states or psychiatric symptoms and studying the genetic variants associated with these facets may help reveal the biological mechanisms underlying psychiatric disorders. In the present study, a meta-analysis of genome-wide association studies for six facets of neuroticism was performed in 5584 participants from three cohorts. Additionally, a Gene Set Enrichment Analysis was conducted to find biological pathways associated with each facet. Six neuroticism facets (N1: anxiety, N2: angry hostility, N3: depre...
Subjects
Medical Subject Headings: mental disorders
free text keywords: Genetics(clinical), Genetics, Hostility, medicine.symptom, medicine, Anxiety, Revised NEO Personality Inventory, Personality, media_common.quotation_subject, media_common, Impulsivity, Genetic association, Neuroticism, Genome-wide association study, Biology, Original Article
Related Organizations
54 references, page 1 of 4

Reynaud, E., El Khoury-Malhame, M., Rossier, J., Blin, O. & Khalfa, S. Neuroticism modifies psychophysiological responses to fearful films. PLoS ONE 7, e32413 (2012).22479326 [OpenAIRE] [PubMed]

Ormel, J., Jeronimus, B. F., Kotov, R., Riese, H., Bos, E. H., Hankin, B. et al. Neuroticism and common mental disorders: meaning and utility of a complex relationship. Clin. Psychol. Rev. 33, 686–697 (2013).23702592 [OpenAIRE] [PubMed]

Brown, T. A. & Rosellini, A. J. The direct and interactive effects of neuroticism and life stress on the severity and longitudinal course of depressive symptoms. J. Abnormal. Psychol. 120, 844–856 (2011).

Costa, P. & McCrae, R. Revised NEO P ersonality Inventory (NEO-PI-R) and NEO Five-Factor Inventory (NEO-FFI) Professional Manual, Psychological Assessment Resources, Odessa, FL, USA, (1992).

Shifman, S., Bhomra, A., Smiley, S., Wray, N. R., James, M. R., Martin, N. G. et al. A whole genome association study of neuroticism using DNA pooling. Mol. Psychiatry 13, 302–312 (2008).17667963 [OpenAIRE] [PubMed]

Terracciano, A., Sanna, S., Uda, M., Deiana, B., Usala, G., Busonero, F. et al. Genome-wide association scan for five major dimensions of personality. Mol. Psychiatry 15, 647–656 (2010).18957941 [OpenAIRE] [PubMed]

Calboli, F. C., Tozzi, F., Galwey, N. W., Antoniades, A., Mooser, V., Preisig, M. et al. A genome-wide association study of neuroticism in a population-based sample. PLoS ONE 5, e11504 (2010).20634892 [OpenAIRE] [PubMed]

Kim, H. N., Roh, S. J., Sung, Y. A., Chung, H. W., Lee, J. Y., Cho, J. et al. Genome-wide association study of the five-factor model of personality in young Korean women. J. Hum. Genet. 58, 667–674 (2013).23903073 [PubMed]

Terraccian o, A., Tanaka, T., Sutin, A. R., Sanna, S., Deiana, B., Lai, S. et al. Genome-wide association scan of trait depression. Biol. Psychiatry 68, 811–817 (2010).20800221 [OpenAIRE] [PubMed]

Smith, D. J., Escott-Price, V., Davies, G., Bailey, M. E., Colodro-Conde, L., Ward, J. et al. Genome-wide analysis of over 106 000 individuals identifies 9 neuroticism-associated loci. Mol. Psychiatry 21, 1644 (2016).27620839 [PubMed]

Okbay, A., Baselmans, B. M., De Neve, J. E., Turley, P., Nivard, M. G., Fontana, M. A. et al. Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses. Nat. Genet. 48, 624–633 (2016).27089181 [OpenAIRE] [PubMed]

de Moor, M. H., van den Berg, S. M., Verweij, K. J., Krueger, R. F., Luciano, M., Arias Vasquez, A. et al. Meta-analysis of genome-wide association studies for neuroticism, and the polygenic association with major depressive disorder. JAMA Psychiatry 72, 642–650 (2015).25993607 [OpenAIRE] [PubMed]

Jang, K. L., McCrae, R. R., Angleitner, A., Riemann, R. & Livesley, W. J. Heritability of facet-level traits in a cross-cultural twin sample: support for a hierarchical model of personality. J. Personal. Soc. Psychol. 74, 1556–1565 (1998).

Hirschhorn, J. N. & Daly, M. J. Genome-wide association studies for common diseases and complex traits. Nat. Rev. Genet. 6, 95–108 (2005).15716906 [PubMed]

Segre, A. V., Groop, L., Mootha, V. K., Daly, M. J. & Altshuler, D. Common inherited variation in mitochondrial genes is not enriched for associations with type 2 diabetes or related glycemic traits. PLoS Genet 6, e1001058 (2010).20714348 [OpenAIRE] [PubMed]

54 references, page 1 of 4
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