publication . Article . Other literature type . 2011

Recognition of S -adenosylmethionine

Robert Batey;
Open Access
  • Published: 12 Jan 2011 Journal: Wiley Interdisciplinary Reviews: RNA, volume 2, pages 299-311 (issn: 1757-7004, Copyright policy)
  • Publisher: Wiley
Riboswitches are regulatory elements commonly found in the 5′ leader sequences of bacterial mRNAs that bind cellular metabolites to direct expression at either the transcriptional or translational level. The effectors of these RNAs are chemically diverse, including nucleobases and nucleosides, amino acids, cofactors, and second messenger molecules. Over the last few years, a number of structures have revealed the architectural means by which RNA creates binding pockets of high affinity and specificity for these compounds. For most effectors, there is a single class of associated riboswitches. However, eight individual classes of S-adenosylmethionine (SAM) and/or...
free text keywords: Biochemistry, Molecular Biology, Article
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