publication . Other literature type . Article . 2012

Preoperative Chemoradiotherapy for Esophageal or Junctional Cancer

P. van Hagen; M.C.C.M. Hulshof; J.J.B. van Lanschot; E.W. Steyerberg; M.I. van Berge Henegouwen; B.P.L. Wijnhoven; D.J. Richel; G.A.P. Nieuwenhuijzen; G.A.P. Hospers; J.J. Bonenkamp; ...
  • Published: 31 May 2012
  • Publisher: Massachusetts Medical Society
Abstract
A B S T R AC T BACKGROUND The role of neoadjuvant chemoradiotherapy in the treatment of patients with esophageal or esophagogastric-junction cancer is not well established. We compared chemoradiotherapy followed by surgery with surgery alone in this patient population. METHODS We randomly assigned patients with resectable tumors to receive surgery alone or weekly administration of carboplatin (doses titrated to achieve an area under the curve of 2 mg per milliliter per minute) and paclitaxel (50 mg per square meter of body-surface area) for 5 weeks and concurrent radiotherapy (41.4 Gy in 23 fractions, 5 days per week), followed by surgery. RESULTS From March 200...
Subjects
free text keywords: Carboplatin, chemistry.chemical_compound, chemistry, Neoadjuvant therapy, medicine.medical_treatment, medicine, Surgery, medicine.medical_specialty, Regimen, Preoperative care, Adenocarcinoma, medicine.disease, Chemoradiotherapy, business.industry, business, Population, education.field_of_study, education, Hazard ratio
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publication . Other literature type . Article . 2012

Preoperative Chemoradiotherapy for Esophageal or Junctional Cancer

P. van Hagen; M.C.C.M. Hulshof; J.J.B. van Lanschot; E.W. Steyerberg; M.I. van Berge Henegouwen; B.P.L. Wijnhoven; D.J. Richel; G.A.P. Nieuwenhuijzen; G.A.P. Hospers; J.J. Bonenkamp; ...