publication . Article . Other literature type . 2016

Genome-Wide Analysis of RNA Secondary Structure.

Zhao Su; Laura E. Ritchey; Sarah M. Assmann; Philip C. Bevilacqua;
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  • Published: 23 Nov 2016 Journal: Annual Review of Genetics, volume 50, pages 235-266 (issn: 0066-4197, eissn: 1545-2948, Copyright policy)
  • Publisher: Annual Reviews
Abstract
Single-stranded RNA molecules fold into extraordinarily complicated secondary and tertiary structures as a result of intramolecular base pairing. In vivo, these RNA structures are not static. Instead, they are remodeled in response to changes in the prevailing physicochemical environment of the cell and as a result of intermolecular base pairing and interactions with RNA-binding proteins. Remarkable technical advances now allow us to probe RNA secondary structure at single-nucleotide resolution and genome-wide, both in vitro and in vivo. These data sets provide new glimpses into the RNA universe. Analyses of RNA structuromes in HIV, yeast, Arabidopsis, and mamma...
Subjects
free text keywords: Nucleic acid secondary structure, Computational biology, Genetics, Intron, Non-coding RNA, Riboswitch, RNA silencing, Small nuclear RNA, RNA, RNA editing, Biology
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