publication . Article . 2017

Silencing of TREM2 exacerbates tau pathology, neurodegenerative changes, and spatial learning deficits in P301S tau transgenic mice

Teng Jiang; Lan Tan; Xi-Chen Zhu; Jun-Shan Zhou; Lei Cao; Meng-Shan Tan; Hui-Fu Wang; Qi Chen; Ying-Dong Zhang; Jin-Tai Yu;
  • Published: 07 Aug 2017
Abstract
Tau pathology is a pathological hallmark for several neurodegenerative diseases including Alzheimer's disease and frontotemporal dementia. As a novel susceptibility gene for these 2 diseases, triggering receptor expressed on myeloid cells 2 (TREM2) gene encodes an immune receptor that is uniquely expressed by microglia. Recently, a correlation between TREM2 expression and hyperphosphorylated tau has been revealed in the brain of Alzheimer's disease patients, suggesting a potential association between TREM2 and tau pathology. However, the role of TREM2 in tau pathology remains unclear thus far. Herein, using P301S mice, we showed that TREM2 was upregulated in mic...
Subjects
Medical Subject Headings: mental disorders
free text keywords: Developmental Biology, Ageing, General Neuroscience, Geriatrics and Gerontology, Clinical Neurology, Immune receptor, Pathology, medicine.medical_specialty, medicine, Frontotemporal dementia, medicine.disease, TREM2, Microglia, medicine.anatomical_structure, Neuroinflammation, GSK-3, Neuroscience, Gene silencing, Neurodegeneration, Psychology
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