publication . Other literature type . Article . 2005

Physiological Changes in Glucose Differentially Modulate the Excitability of Hypothalamic Melanin-Concentrating Hormone and Orexin Neurons In Situ

Denis Burdakov; Oleg Gerasimenko; Alexei Verkhratsky;
Open Access English
  • Published: 02 Mar 2005
  • Publisher: Society for Neuroscience
Abstract
The physiological signaling mechanisms that link normal variations in body energy status to the activity of arousal- and metabolism-regulating brain centers are not well understood. The melanin-concentrating hormone (MCH) and orexin/hypocretin types of neurons of the lateral hypothalamus (LH) exert opposing effects on arousal and metabolism. We examined whether shifts in brain extracellular glucose that correspond to physiological changes in blood glucose can alter the electrical output of neurochemically and biophysically defined LH cells in mouse brain slices. Here, we show that physiologically relevant concentrations of glucose dose-dependently enhance the el...
Subjects
Medical Subject Headings: nervous system
free text keywords: Brief Communications, General Neuroscience
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