publication . Article . Other literature type . 2002

Memory CD8+ T cells vary in differentiation phenotype in different persistent virus infections.

Celsa A. Spina; Abigail S. King; Douglas D. Richman; Graham S. Ogg; Margaret F. C. Callan; Vincenzo Cerundolo; Andrew J. McMichael; Laura Papagno; Anele Waters; Susan J. Little; ...
Restricted English
  • Published: 01 Apr 2002 Journal: Nature medicine, volume 8, issue 4 (issn: 1078-8956, eissn: 1546-170X, Copyright policy)
  • Country: United Kingdom
Abstract
The viruses HIV-1, Epstein-Barr virus (EBV), cytomegalovirus (CMV) and hepatitis C virus (HCV) are characterized by the establishment of lifelong infection in the human host, where their replication is thought to be tightly controlled by virus-specific CD8+ T cells. Here we present detailed studies of the differentiation phenotype of these cells, which can be separated into three distinct subsets based on expression of the costimulatory receptors CD28 and CD27. Whereas CD8+ T cells specific for HIV, EBV and HCV exhibit similar characteristics during primary infection, there are significant enrichments at different stages of cellular differentiation in the chroni...
Subjects
Medical Subject Headings: virus diseases
free text keywords: General Biochemistry, Genetics and Molecular Biology, General Medicine, CD8, Effector, CD28, Cytotoxic T cell, Immunology, Biology, Phenotype, Hepatitis C virus, medicine.disease_cause, medicine, Cellular differentiation, Virus, Virology
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