publication . Article . Other literature type . 2015

From the genetic architecture to synaptic plasticity in autism spectrum disorder

Thomas Bourgeron;
Open Access English
  • Published: 20 Aug 2015
  • Publisher: HAL CCSD
  • Country: France
International audience; Genetics studies of autism spectrum disorder (ASD) have identified several risk genes that are key regulators of synaptic plasticity. Indeed, many of the risk genes that have been linked to these disorders encode synaptic scaffolding proteins, receptors, cell adhesion molecules or proteins that are involved in chromatin remodelling, transcription, protein synthesis or degradation, or actin cytoskeleton dynamics. Changes in any of these proteins can increase or decrease synaptic strength or number and, ultimately, neuronal connectivity in the brain. In addition, when deleterious mutations occur, inefficient genetic buffering and impaired s...
free text keywords: Synaptic plasticity, Autism spectrum disorders, Genetics of the nervous system, MESH: Brain, MESH: Child Development Disorders, Pervasive, MESH: Humans, MESH: Neuronal Plasticity, MESH: Synapses, [SDV.GEN.GH]Life Sciences [q-bio]/Genetics/Human genetics, [SDV.MHEP.PSM]Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health, General Neuroscience
Download fromView all 6 versions
Article . 2015
Provider: Hal-Diderot
Article . 2015
Provider: HAL-Inserm
Article . 2015
Provider: HAL-Pasteur
Powered by OpenAIRE Research Graph
Any information missing or wrong?Report an Issue