publication . Article . Other literature type . 2015

From the genetic architecture to synaptic plasticity in autism spectrum disorder

Thomas Bourgeron;
Open Access English
  • Published: 20 Aug 2015
  • Publisher: HAL CCSD
  • Country: France
Abstract
International audience; Genetics studies of autism spectrum disorder (ASD) have identified several risk genes that are key regulators of synaptic plasticity. Indeed, many of the risk genes that have been linked to these disorders encode synaptic scaffolding proteins, receptors, cell adhesion molecules or proteins that are involved in chromatin remodelling, transcription, protein synthesis or degradation, or actin cytoskeleton dynamics. Changes in any of these proteins can increase or decrease synaptic strength or number and, ultimately, neuronal connectivity in the brain. In addition, when deleterious mutations occur, inefficient genetic buffering and impaired s...
Subjects
free text keywords: Synaptic plasticity, Autism spectrum disorders, Genetics of the nervous system, MESH: Brain, MESH: Child Development Disorders, Pervasive, MESH: Humans, MESH: Neuronal Plasticity, MESH: Synapses, [SDV.GEN.GH]Life Sciences [q-bio]/Genetics/Human genetics, [SDV.MHEP.PSM]Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health, General Neuroscience
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