publication . Other literature type . Article . 2005

Current Status of Gastrointestinal Carcinoids

Irvin M. Modlin; Mark Kidd; Igor Latich; Michelle N. Zikusoka; Michael D. Shapiro;
  • Published: 01 May 2005
  • Publisher: Elsevier BV
Abstract
Gastrointestinal (GI) carcinoids are ill-understood, enigmatic malignancies, which, although slow growing compared with adenocarcinomas, can behave aggressively. Carcinoids are classified based on organ site and cell of origin and occur most frequently in the GI (67%) where they are most common in small intestine (25%), appendix (12%), and rectum (14%). Local manifestations—mass, bleeding, obstruction, or perforation—reflect invasion or tumor-induced fibrosis and often result in incidental detection at emergency surgery. Symptoms are protean (flushing, sweating, diarrhea, bronchospasm), usually misdiagnosed, and reflect secretion of diverse amines and peptides. ...
Subjects
Medical Subject Headings: digestive system diseases
free text keywords: Gastroenterology, Neuroendocrine tumors, medicine.disease, medicine, Transplantation, medicine.medical_specialty, Rectum, medicine.anatomical_structure, Pathology, business.industry, business, Somatostatinoma, Carcinoembryonic antigen, biology.protein, biology, Appendix, General surgery, Radiation therapy, medicine.medical_treatment, Internal medicine, Embolization
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publication . Other literature type . Article . 2005

Current Status of Gastrointestinal Carcinoids

Irvin M. Modlin; Mark Kidd; Igor Latich; Michelle N. Zikusoka; Michael D. Shapiro;