publication . Article . Other literature type . 2016

Meta-analysis identifies common and rare variants influencing blood pressure and overlapping with metabolic trait loci

Jeanette M. Stafford; Stefan Weiss; Lisa W. Martin; I-Te Lee; Fotios Drenos; Fotios Drenos; Krystal S Tsosie; Heribert Schunkert; Daniel I. Chasman; Paul L. Auer; ...
Open Access English
  • Published: 12 Sep 2016
Abstract
textabstractMeta-analyses of association results for blood pressure using exome-centric single-variant and gene-based tests identified 31 new loci in a discovery stage among 146,562 individuals, with follow-up and meta-analysis in 180,726 additional individuals (total n = 327,288). These blood pressure-associated loci are enriched for known variants for cardiometabolic traits. Associations were also observed for the aggregation of rare and low-frequency missense variants in three genes, NPR1, DBH, and PTPMT1. In addition, blood pressure associations at 39 previously reported loci were confirmed. The identified variants implicate biological pathways related to ca...
Subjects
free text keywords: Blood Pressure/genetics, Exome, Genetic Variation, Genome, Human, Genome-Wide Association Study, Genotype, Humans, Hypertension/genetics, Oligonucleotide Array Sequence Analysis, Polymorphism, Single Nucleotide, Genetics, Article, CHD Exome+ Consortium, ExomeBP Consortium, GoT2DGenes Consortium, T2D-GENES Consortium, Myocardial Infarction Genetics and CARDIoGRAM Exome Consortia, CKDGen Consortium, Hypertension, Polymorphism, Single Nucleotide, Genome, Human, ddc:616, Polymorphism (computer science), Blood pressure, Locus (genetics), Gene, Biology
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