publication . Article . Other literature type . 2016

Meta-analysis identifies common and rare variants influencing blood pressure and overlapping with metabolic trait loci

Name: Meta-analysis identifies common and rare variants influencing blood pressure and overlapping with metabolic trait loci
Keywords: Blood Pressure/genetics, Exome, Genetic Variation, Genome, Human, Genome-Wide Association Study, Genotype, Humans, Hypertension/genetics, Oligonucleotide Array Sequence Analysis, Polymorphism, Single Nucleotide, Genetics, Article, CHD Exome+ Consortium, ExomeBP Consortium, GoT2DGenes Consortium, T2D-GENES Consortium, Myocardial Infarction Genetics and CARDIoGRAM Exome Consortia, CKDGen Consortium, Hypertension, Polymorphism, Single Nucleotide, Genome, Human

Jeanette M. Stafford; Stefan Weiss; Lisa W. Martin; I-Te Lee; Fotios Drenos; Fotios Drenos; Krystal S Tsosie; Heribert Schunkert; Daniel I. Chasman; Paul L. Auer; ...

View all 106 authors

Open Access English

Published: 12 Sep 2016

Summary

Abstract

textabstractMeta-analyses of association results for blood pressure using exome-centric single-variant and gene-based tests identified 31 new loci in a discovery stage among 146,562 individuals, with follow-up and meta-analysis in 180,726 additional individuals (total n = 327,288). These blood pressure-associated loci are enriched for known variants for cardiometabolic traits. Associations were also observed for the aggregation of rare and low-frequency missense variants in three genes, NPR1, DBH, and PTPMT1. In addition, blood pressure associations at 39 previously reported loci were confirmed. The identified variants implicate biological pathways related to ca...

doi: 10.1038/ng.3660 , 10.17863/cam.15650 , 10.17615/v3jt-ap14

View all 6 identifiers

Subjects

free text keywords: Blood Pressure/genetics, Exome, Genetic Variation, Genome, Human, Genome-Wide Association Study, Genotype, Humans, Hypertension/genetics, Oligonucleotide Array Sequence Analysis, Polymorphism, Single Nucleotide, Genetics, Article, CHD Exome+ Consortium, ExomeBP Consortium, GoT2DGenes Consortium, T2D-GENES Consortium, Myocardial Infarction Genetics and CARDIoGRAM Exome Consortia, CKDGen Consortium, Hypertension, Polymorphism, Single Nucleotide, Genome, Human, ddc:616, Polymorphism (computer science), Blood pressure, Locus (genetics), Gene, Biology

Related Organizations

University of Cambridge
United Kingdom
University of Northwestern
United States
DHHS - National Institutes of Health
United States

Download fromView all 9 versions

Brunel University Research Archive

Article . 2016

Provider: Brunel University Research Archive

NARCIS

Article . 2016

Provider: NARCIS

Nature Genetics

Article

Provider: UnpayWall

Europe PubMed Central

Other literature type . 2016

Provider: PubMed Central

Any information missing or wrong?Report an Issue