publication . Article . 2000

Oxidative stress in bacteria and protein damage by reactive oxygen species

Cabiscol Català, Elisa; Tamarit Sumalla, Jordi; Ros Salvador, Joaquim;
Open Access
  • Published: 01 Jan 2000
  • Publisher: Springer-Verlag Ibérica
  • Country: Spain
Abstract
The advent of O2 in the atmosphere was among the first major pollution events occurred on earth. The reaction between ferrous iron, very abundant in the reductive early atmosphere, and oxygen results in the formation of harmful superoxide and hydroxyl radicals, which affect all macromolecules (DNA, lipids and proteins). Living organisms have to build up mechanisms to protect themselves against oxidative stress, with enzymes such as catalase and superoxide dismutase, small proteins like thioredoxin and glutaredoxin, and molecules such as glutathione. Bacterial genetic responses to oxidative stress are controlled by two major transcriptional regulators (OxyR and S...
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Subjects
free text keywords: Oxygen, Oxidative stress, Reactive oxygen species, Protein oxidation
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