publication . Other literature type . Article . 2007

Human population structure detection via multilocus genotype clustering

Gao, Xiaoyi; Starmer, Joshua;
Open Access
  • Published: 25 Jun 2007
  • Publisher: Springer Science and Business Media LLC
<p>Abstract</p> <p>Background</p> <p>We describe a hierarchical clustering algorithm for using Single Nucleotide Polymorphism (SNP) genetic data to assign individuals to populations. The method does not assume Hardy-Weinberg equilibrium and linkage equilibrium among loci in sample population individuals.</p> <p>Results</p> <p>We show that the algorithm can assign sample individuals highly accurately to their corresponding ethnic groups in our tests using HapMap SNP data and it is also robust to admixed populations when tested with Perlegen SNP data. Moreover, it can detect fine-scale population structure as subtle as that between Chinese and Japanese by using ge...
free text keywords: Research Article, Genetics, QH426-470, Genetics(clinical)
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