publication . Other literature type . Article . 2013

Alternative cleavage and polyadenylation: extent, regulation and function

Reuven Agami; Alejandro Pineiro Ugalde; Ran Elkon;
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  • Published: 18 Jun 2013
  • Publisher: Springer Science and Business Media LLC
Abstract
The 3' end of most protein-coding genes and long non-coding RNAs is cleaved and polyadenylated. Recent discoveries have revealed that a large proportion of these genes contains more than one polyadenylation site. Therefore, alternative polyadenylation (APA) is a widespread phenomenon, generating mRNAs with alternative 3' ends. APA contributes to the complexity of the transcriptome by generating isoforms that differ either in their coding sequence or in their 3' untranslated regions (UTRs), thereby potentially regulating the function, stability, localization and translation efficiency of target RNAs. Here, we review our current understanding of the polyadenylatio...
Subjects
Medical Subject Headings: psychological phenomena and processesmental disorderseducation
free text keywords: Genetics(clinical), Genetics, Molecular Biology, RNA, Coding region, Computational biology, Biology, Untranslated region, Gene, RNA splicing, Alternative splicing, Polyadenylation, Three prime untranslated region
Funded by
EC| MIREG
Project
MIREG
Identifying novel regulatory mechanisms of miRNA functions
  • Funder: European Commission (EC)
  • Project Code: 201900
  • Funding stream: FP7 | SP2 | ERC
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