publication . Article . Other literature type . 2004

A gene expression signature for recent onset rheumatoid arthritis in peripheral blood mononuclear cells

Olsen, N; Sokka, T; Seehorn, C; Kraft, B; Maas, K; Moore, J; Aune, T;
Open Access
  • Published: 01 Nov 2004 Journal: Annals of the Rheumatic Diseases, volume 63, pages 1,387-1,392 (issn: 0003-4967, Copyright policy)
  • Publisher: BMJ
Abstract
Background: In previous studies the presence of a distinct gene expression pattern has been shown in peripheral blood cells from patients with autoimmune disease. Objective: To determine whether other specific signatures might be used to identify subsets of these autoimmune diseases and whether gene expression patterns in early disease might identify pathogenetic factors. Methods: Peripheral blood mononuclear cells were acquired from patients with rheumatoid arthritis (RA) and analysed by microarrays containing over 4300 named human genes. Patients with RA for Results: Cluster analyses permitted separation of the patients with early RA (ERA) from those with long...
Subjects
free text keywords: Connective tissue disease, medicine.disease, medicine, Systemic lupus erythematosus, Immune system, Lupus erythematosus, business.industry, business, Immunology, Internal medicine, medicine.medical_specialty, Rheumatology, Peripheral blood mononuclear cell, Autoimmune disease, Rheumatoid arthritis, Extended Report
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