publication . Article . Other literature type . 2007

RanBPM, a Scaffolding Protein in the Immune and Nervous Systems

Murrin, L. Charles; Talbot, Jeffery N.;
  • Published: 28 Jun 2007
Abstract
We review the literature for Ran Binding Protein in the Microtubule-Organizing Center (RanBPM; RanBP9), a 90-kDa protein that possesses many characteristics of a scaffolding protein, including protein-interaction motifs, a cytoskeletal-binding domain, and multiple canonical docking sites for signaling intermediates. We focus on studies that have examined functional interactions between RanBPM and other proteins. These studies suggest that RanBPM provides a platform for the interaction of a variety of signaling proteins, including cell surface receptors, nuclear receptors, nuclear transcription factors, and cytosolic kinases. These studies indicate that RanBPM ac...
Subjects
free text keywords: Immunology, Immunology and Allergy, Pharmacology, Neuroscience (miscellaneous), Signal transduction, Scaffold protein, Transcription factor, Docking (dog), Cell surface receptor, Kinase, Cytosol, Cell biology, Biology, Nuclear receptor
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