publication . Article . 2015

Effect of MTHFR, TGFβ1, and TNFB polymorphisms on osteoporosis in rheumatoid arthritis patients

Mohamed N. Saad; Mai S. Mabrouk; Ayman M. Eldeib; Olfat G. Shaker;
  • Published: 15 May 2015
  • Publisher: Elsevier BV
Abstract
Abstract Diseases of the immune and the skeletal systems should be studied together for the deep interaction between them. Many studies consider osteoporosis (OP) as a risk factor for the prediction of disease progression in rheumatoid arthritis (RA). The aim of this research is to study the effect of four single nucleotide polymorphisms (SNPs) on RA patients with and without OP. The examined SNPs (MTHFR (C677T, and A1298C), TGFβ1 (T869C), and TNFB (A252G)) were tested by genotyping 17 RA patients with OP and 72 RA patients without OP. Associations were tested using four models (multiplicative, dominant, recessive, and co-dominant). The studied SNPs were not sig...
Subjects
free text keywords: Genetics, General Medicine, Methylenetetrahydrofolate reductase, biology.protein, biology, Genotyping, Risk factor, Single-nucleotide polymorphism, Osteoporosis, medicine.disease, medicine, Dominance (genetics), Population, education.field_of_study, education, Rheumatoid arthritis
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publication . Article . 2015

Effect of MTHFR, TGFβ1, and TNFB polymorphisms on osteoporosis in rheumatoid arthritis patients

Mohamed N. Saad; Mai S. Mabrouk; Ayman M. Eldeib; Olfat G. Shaker;