publication . Article . Other literature type . 2011

Long term in vivo biotransformation of iron oxide nanoparticles.

Name: Long term in vivo biotransformation of iron oxide nanoparticles.
Keywords: NANOPARTICLES, NANOMAGNETISM, NANOTOXICITY, BIODEGRADATION, IRON OXIDE, CONTRAST AGENT, [SDV.TOX]Life Sciences [q-bio]/Toxicology, [SDE]Environmental Sciences, Biophysics, Mechanics of Materials, Bioengineering, Biomaterials, Ceramics and Composites

Florence Gazeau; Cécile Factor; Vanessa Deveaux; Nathalie Luciani; Sophie Lotersztajn; Dan Elgrabli; Claire Wilhelm; Francois Gendron; Damien Alloyeau; Christine Péchoux; ...

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Open Access English

Published: 01 Jun 2011

Publisher: HAL CCSD

Country: France

Summary

Abstract

International audience; The long term outcome of nanoparticles in the organism is one of the most important concerns raised by the development of nanotechnology and nanomedicine. Little is known on the way taken by cells to process and degrade nanoparticles over time. In this context, iron oxide superparamagnetic nanoparticles benefit from a privileged status, because they show a very good tolerance profile, allowing their clinical use for MRI diagnosis. It is generally assumed that the specialized metabolism which regulates iron in the organism can also handle iron oxide nanoparticles. However the biotransformation of iron oxide nanoparticles is still not eluci...

doi: 10.1016/j.biomaterials.2011.02.031

Subjects

free text keywords: NANOPARTICLES, NANOMAGNETISM, NANOTOXICITY, BIODEGRADATION, IRON OXIDE, CONTRAST AGENT, [SDV.TOX]Life Sciences [q-bio]/Toxicology, [SDE]Environmental Sciences, Biophysics, Mechanics of Materials, Bioengineering, Biomaterials, Ceramics and Composites, Iron oxide nanoparticles, chemistry.chemical_compound, chemistry, Superparamagnetism, Nanotechnology, Nanotoxicology, Nanomedicine, Ferritin, biology.protein, biology, Nanoparticle, Materials science, Biotransformation

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