publication . Article . Other literature type . 2011

Long term in vivo biotransformation of iron oxide nanoparticles.

Florence Gazeau; Cécile Factor; Vanessa Deveaux; Nathalie Luciani; Sophie Lotersztajn; Dan Elgrabli; Claire Wilhelm; Francois Gendron; Damien Alloyeau; Christine Péchoux; ...
Open Access English
  • Published: 01 Jun 2011
  • Publisher: HAL CCSD
  • Country: France
Abstract
International audience; The long term outcome of nanoparticles in the organism is one of the most important concerns raised by the development of nanotechnology and nanomedicine. Little is known on the way taken by cells to process and degrade nanoparticles over time. In this context, iron oxide superparamagnetic nanoparticles benefit from a privileged status, because they show a very good tolerance profile, allowing their clinical use for MRI diagnosis. It is generally assumed that the specialized metabolism which regulates iron in the organism can also handle iron oxide nanoparticles. However the biotransformation of iron oxide nanoparticles is still not eluci...
Subjects
free text keywords: NANOPARTICLES, NANOMAGNETISM, NANOTOXICITY, BIODEGRADATION, IRON OXIDE, CONTRAST AGENT, [SDV.TOX]Life Sciences [q-bio]/Toxicology, [SDE]Environmental Sciences, Biophysics, Mechanics of Materials, Bioengineering, Biomaterials, Ceramics and Composites, Iron oxide nanoparticles, chemistry.chemical_compound, chemistry, Superparamagnetism, Nanotechnology, Nanotoxicology, Nanomedicine, Ferritin, biology.protein, biology, Nanoparticle, Materials science, Biotransformation
Funded by
EC| MAGNIFYCO
Project
MAGNIFYCO
MAGNETIC NANOCONTAINERS FOR COMBINED HYPERTHERMIA AND CONTROLLED DRUG RELEASE
  • Funder: European Commission (EC)
  • Project Code: 228622
  • Funding stream: FP7 | SP1 | NMP
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