publication . Other literature type . Article . 2007

Cerebrospinal Fluid tau/β-Amyloid42 Ratio as a Prediction of Cognitive Decline in Nondemented Older Adults

Anne M. Fagan; Catherine M. Roe; Chengjie Xiong; Mark A. Mintun; John C. Morris; David M. Holtzman;
  • Published: 01 Mar 2007
  • Publisher: American Medical Association (AMA)
Abstract
Objectives To investigate the ability of cerebrospinal fluid (CSF) and plasma measures to discriminate early-stage Alzheimer disease (AD) (defined by clinical criteria and presence/absence of brain amyloid) from nondemented aging and to assess whether these biomarkers can predict future dementia in cognitively normal individuals. Design Evaluation of CSF β-amyloid 40 (Aβ 40 ), Aβ 42 , tau, phosphorylated tau 181 , and plasma Aβ 40 and Aβ 42 and longitudinal clinical follow-up (from 1 to 8 years). Setting Longitudinal studies of healthy aging and dementia through an AD research center. Participants Community-dwelling volunteers (n = 139) aged 60 to 91 years and c...
Subjects
Medical Subject Headings: mental disorders
free text keywords: Medicine, business.industry, business, Internal medicine, medicine.medical_specialty, Neuroscience, Cognitive decline, Oncology, Anesthesia, Dementia, medicine.disease, Cognitive disorder, Clinical Dementia Rating, Alzheimer's disease biomarkers, Cerebrospinal fluid, Pittsburgh compound B, chemistry.chemical_compound, chemistry, Alzheimer's disease
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