publication . Other literature type . Article . 2012

Soluble Trem-like Transcript-1 Regulates Leukocyte Activation and Controls Microbial Sepsis

Derive, Marc; Bouazza, Youcef; Sennoun, Nacira; Marchionni, Sandra; Quigley, Laura; Washington, Valance; Massin, Frédéric; Max, Jean-Pierre; Ford, Jill; Alauzet, Corentine; ...
Open Access English
  • Published: 02 May 2012
Abstract
The triggering receptor expressed on myeloid cells (TREM)-1 plays a crucial role during the onset of sepsis by amplifying the host immune response. The TREM-like transcript-1 (TLT-1) belongs to the TREM family, is selectively expressed on activated platelets, and is known to facilitate platelet aggregation through binding to fibrinogen. In this study, we show that a soluble form of TLT-1 is implicated in the regulation of inflammation during sepsis by dampening leukocyte activation and modulating platelet-neutrophil crosstalk. A 17-aa sequence of the TLT-1 extracellular domain (LR17) is responsible for this activity through competition with the TREM-1 ligand. Wh...
Subjects
free text keywords: Article, Immunology, Extracellular, Regulator, Fibrinogen, medicine.drug, medicine, Immune system, Inflammation, medicine.symptom, Platelet, Receptor, Sepsis, medicine.disease, Biology
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