publication . Article . Other literature type . 2010

Effects of allopurinol on uric acid concentrations, xanthine oxidoreductase activity and oxidative stress in broiler chickens

Carro, M.D.; Falkenstein, E.; Radke, W.J.; Klandorf, H.;
  • Published: 01 Jan 2010 Journal: Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, volume 151, pages 12-17 (issn: 1532-0456, Copyright policy)
  • Publisher: Elsevier BV
Abstract The purpose of this study was to determine the effects of allopurinol (AL) on xanthine oxidoreductase (XOR) activity and uric acid (UA) levels in chickens. Thirty 5-week-old broilers were divided into three groups and fed 0 (control), 25 (AL25) or 50 (AL50) mg AL per kg of body mass for 5 weeks. Chicks were weighed twice weekly and leukocyte oxidative activity (LOA) and plasma purine levels were determined weekly in five birds per group. Chicks were sacrificed after 2 or 5 weeks, and samples from tissues were taken for analysis of XOR activity. Plasma UA concentrations were lower (P   0.05) in XOR activity in the pancreas and intestine. These results su...
free text keywords: Toxicology, Cell Biology, Biochemistry, Physiology, Health, Toxicology and Mutagenesis, General Medicine, Uric acid, chemistry.chemical_compound, chemistry, Allantoin, Purine, Hypoxanthine, Xanthine, Broiler, Biology, Allopurinol, medicine.drug, medicine, Oxidative stress, medicine.disease_cause, Internal medicine, medicine.medical_specialty, Endocrinology
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