publication . Other literature type . Article . 2009

Prognostic factors in ALS: A critical review

Chiò, Adriano; Logroscino, Giancarlo; Hardiman, Orla; Swingler, Robert; Mitchell, Douglas; Beghi, Ettore; Traynor, Bryan G; Couratier, Philippe;
Open Access English
  • Published: 18 Nov 2009
Abstract
International audience; We have performed a systematic review to summarize current knowledge concerning factors related to survival in ALS and to evaluate the implications of these data for clinical trials design. The median survival time from onset to death ranges from 20 to 48 months, but 10-20% of ALS patients have a survival longer than 10 years. Older age and bulbar onset are consistently reported to have a worse outcome. There are conflicting data on gender, diagnostic delay and El Escorial criteria. The rate of symptom progression was revealed to be an independent prognostic factor. Psychosocial factors, FTD, nutritional status, and respiratory function a...
Subjects
free text keywords: Article, MESH: Age of Onset, MESH: Amyotrophic Lateral Sclerosis, MESH: Retrospective Studies, MESH: Severity of Illness Index, MESH: Survival Rate, MESH: Biological Markers, MESH: Clinical Trials as Topic, MESH: Disease Progression, MESH: Humans, MESH: Nutritional Status, MESH: Prognosis, MESH: Prospective Studies, MESH: Respiration, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Amyotrophic lateral sclerosis, medicine.disease, medicine, Prognostic factor, business.industry, business, Respiratory function, Clinical trial, Parenteral nutrition, Randomization, Psychosocial, Physical therapy, medicine.medical_specialty, Neurology, Clinical Neurology, General Medicine
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