publication . Article . Other literature type . 2014

Association of genetic variation of sodium taurocholate cotransporting polypeptide with chronic hepatitis B virus infection.

Li, Na; Zhang, Pingping; Yang, Cuiling; Zhu, Qianqian; Li, Zhu; Li, Fang; Han, Qunying; Wang, Yawen; Lv, Yi; Wei, Ping; ...
Open Access
  • Published: 01 Jun 2014 Journal: Genetic Testing and Molecular Biomarkers, volume 18, pages 425-429 (issn: 1945-0265, eissn: 1945-0257, Copyright policy)
  • Publisher: Mary Ann Liebert Inc
Abstract
Background: Sodium taurocholate cotransporting polypeptide (NTCP) plays an important role in the enterohepatic circulation of bile acids and hepatocyte function and was recently proposed to be a functional receptor for hepatitis B virus (HBV). Objective: This study investigated the association of the functional polymorphism c.800C>T (p.S267F) (rs2296651) of the NTCP gene with HBV infection. Methods: The study included 244 patients with chronic HBV infection, 76 HBV infection resolvers, and 113 healthy controls. The polymorphism was genotyped using the polymerase chain reaction–restriction fragment length polymorphism method. Results: The distribution of the geno...
Subjects
Medical Subject Headings: digestive system diseasesvirus diseases
free text keywords: Genetics(clinical), General Medicine, Original Articles
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