publication . Article . Other literature type . 2006

Acute myocardial infarction and heart failure : Role of apoptosis

Abbate, Antonio; Bussani, Rossana; Amin, Mitesh S.; Vetrovec, George W.; Baldi, Alfonso;
Restricted
  • Published: 01 Jan 2006 Journal: The International Journal of Biochemistry & Cell Biology, volume 38, pages 1,834-1,840 (issn: 1357-2725, Copyright policy)
  • Publisher: Elsevier BV
  • Country: Italy
Abstract
Apoptosis is a key pathologic feature in acute myocardial infarction and heart failure. Experimental animal studies have shown beneficial effects of inhibiting apoptosis. Understanding the mechanisms involved in the apoptotic cascade may be useful in better understanding of heart failure and its management. Not only in vivo detection of apoptosis may prove clinically useful in the diagnosis and risk stratification of patients with ischemic heart disease, but anti-apoptotic treatments (specific and non-specific) may be effective in the prevention and treatment of post-infarction remodelling and heart failure. © 2006 Elsevier Ltd. All rights reserved.
Subjects
free text keywords: Cell Biology, Biochemistry, Disease, Myocardial infarction, medicine.disease, medicine, Internal medicine, medicine.medical_specialty, Molecular biology, Heart failure, Ischemic heart, Biology, In vivo, Cardiology, Apoptosis, Animal studies, Cardiac remodelling, Therapy
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