publication . Article . Other literature type . 2008

Adaptive design methods in clinical trials - a review.

Chow, Shein-Chung; Chang, Mark;
Open Access
  • Published: 02 May 2008 Journal: Orphanet Journal of Rare Diseases, volume 3 (eissn: 1750-1172, Copyright policy)
  • Publisher: Springer Nature
Abstract
<p>Abstract</p> <p>In recent years, the use of adaptive design methods in clinical research and development based on accrued data has become very popular due to its flexibility and efficiency. Based on adaptations applied, adaptive designs can be classified into three categories: prospective, concurrent (ad hoc), and retrospective adaptive designs. An adaptive design allows modifications made to trial and/or statistical procedures of ongoing clinical trials. However, it is a concern that the actual patient population after the adaptations could deviate from the originally target patient population and consequently the overall type I error (to erroneously claim e...
Subjects
free text keywords: Genetics(clinical), Pharmacology (medical), General Medicine, Medicine(all), Medicine, R, Review
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