publication . Article . Other literature type . 2019

An Adversarial DNA N6-Methyladenine-Sensor Network Preserves Polycomb Silencing.

Klimašauskas;
Open Access English
  • Published: 01 Jun 2019 Journal: Molecular Cell, volume 74, issue 6, pages 1,138-1,147,000,000 (issn: 10972765, Copyright policy)
Abstract
Highlights • 6mA deposition and erasure by mammalian Mettl4 and Alkbh4, respectively • Mettl4-deficient mice display craniofacial dysmorphism • 6mA triggers proteolysis of its cognate sensor proteins ASXL1 and MPND • Adversarial 6mA network architecture preserves Polycomb silencing
Subjects
free text keywords: Article, 6mA, DNA methylation, TRIP12, ASXL1, MPND, METTL4, ALKBH4, ALKBH1, Cell Biology, Molecular Biology
Related Organizations
Funded by
EC| EpiTrack
Project
EpiTrack
Single-cell temporal tracking of epigenetic DNA marks
  • Funder: European Commission (EC)
  • Project Code: 742654
  • Funding stream: H2020 | ERC | ERC-ADG
60 references, page 1 of 4

Abeles, A., Brendler, T., Austin, S.. Evidence of two levels of control of P1 oriR and host oriC replication origins by DNA adenine methylation. J. Bacteriol.. 1993; 175: 7801-7807 [OpenAIRE] [PubMed]

Aravind, L., Iyer, L.M.. The HARE-HTH and associated domains: novel modules in the coordination of epigenetic DNA and protein modifications. Cell Cycle. 2012; 11: 119-131 [OpenAIRE] [PubMed]

Asada, S., Goyama, S., Inoue, D., Shikata, S., Takeda, R., Fukushima, T., Yonezawa, T., Fujino, T., Hayashi, Y., Kawabata, K.C.. Mutant ASXL1 cooperates with BAP1 to promote myeloid leukaemogenesis. Nat. Commun.. 2018; 9: 2733 [OpenAIRE] [PubMed]

Au, K.G., Welsh, K., Modrich, P.. Initiation of methyl-directed mismatch repair. J. Biol. Chem.. 1992; 267: 12142-12148 [PubMed]

Balasubramani, A., Larjo, A., Bassein, J.A., Chang, X., Hastie, R.B., Togher, S.M., Lähdesmäki, H., Rao, A.. Cancer-associated ASXL1 mutations may act as gain-of-function mutations of the ASXL1-BAP1 complex. Nat. Commun.. 2015; 6: 7307 [OpenAIRE] [PubMed]

Bosselut, R.. Pleiotropic functions of H3K27Me3 demethylases in immune cell differentiation. Trends Immunol.. 2016; 37: 102-113 [OpenAIRE] [PubMed]

Boultwood, J., Perry, J., Pellagatti, A., Fernandez-Mercado, M., Fernandez-Santamaria, C., Calasanz, M.J., Larrayoz, M.J., Garcia-Delgado, M., Giagounidis, A., Malcovati, L.. Frequent mutation of the polycomb-associated gene ASXL1 in the myelodysplastic syndromes and in acute myeloid leukemia. Leukemia. 2010; 24: 1062-1065 [PubMed]

Bramswig, N.C., Lüdecke, H.J., Pettersson, M., Albrecht, B., Bernier, R.A., Cremer, K., Eichler, E.E., Falkenstein, D., Gerdts, J., Jansen, S.. Identification of new TRIP12 variants and detailed clinical evaluation of individuals with non-syndromic intellectual disability with or without autism. Hum. Genet.. 2017; 136: 179-192 [OpenAIRE] [PubMed]

Bryson, A.L., Hwang, Y., Sherrill-Mix, S., Wu, G.D., Lewis, J.D., Black, L., Clark, T.A., Bushman, F.D.. Covalent modification of bacteriophage T4 DNA inhibits CRISPR-Cas9. MBio. 2015; 6: e00648 [OpenAIRE] [PubMed]

Bujnicki, J.M., Feder, M., Radlinska, M., Blumenthal, R.M.. Structure prediction and phylogenetic analysis of a functionally diverse family of proteins homologous to the MT-A70 subunit of the human mRNA:m(6)A methyltransferase. J. Mol. Evol.. 2002; 55: 431-444 [OpenAIRE] [PubMed]

Cong, L., Ran, F.A., Cox, D., Lin, S., Barretto, R., Habib, N., Hsu, P.D., Wu, X., Jiang, W., Marraffini, L.A., Zhang, F.. Multiplex genome engineering using CRISPR/Cas systems. Science. 2013; 339: 819-823 [OpenAIRE] [PubMed]

Dey, A., Seshasayee, D., Noubade, R., French, D.M., Liu, J., Chaurushiya, M.S., Kirkpatrick, D.S., Pham, V.C., Lill, J.R., Bakalarski, C.E.. Loss of the tumor suppressor BAP1 causes myeloid transformation. Science. 2012; 337: 1541-1546 [OpenAIRE] [PubMed]

Dominissini, D., Moshitch-Moshkovitz, S., Schwartz, S., Salmon-Divon, M., Ungar, L., Osenberg, S., Cesarkas, K., Jacob-Hirsch, J., Amariglio, N., Kupiec, M.. Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq. Nature. 2012; 485: 201-206 [OpenAIRE] [PubMed]

Frickey, T., Lupas, A.. CLANS: a Java application for visualizing protein families based on pairwise similarity. Bioinformatics. 2004; 20: 3702-3704 [OpenAIRE] [PubMed]

Fu, Y., Luo, G.Z., Chen, K., Deng, X., Yu, M., Han, D., Hao, Z., Liu, J., Lu, X., Doré, L.C.. N6-methyldeoxyadenosine marks active transcription start sites in Chlamydomonas. Cell. 2015; 161: 879-892 [OpenAIRE] [PubMed]

60 references, page 1 of 4
Abstract
Highlights • 6mA deposition and erasure by mammalian Mettl4 and Alkbh4, respectively • Mettl4-deficient mice display craniofacial dysmorphism • 6mA triggers proteolysis of its cognate sensor proteins ASXL1 and MPND • Adversarial 6mA network architecture preserves Polycomb silencing
Subjects
free text keywords: Article, 6mA, DNA methylation, TRIP12, ASXL1, MPND, METTL4, ALKBH4, ALKBH1, Cell Biology, Molecular Biology
Related Organizations
Funded by
EC| EpiTrack
Project
EpiTrack
Single-cell temporal tracking of epigenetic DNA marks
  • Funder: European Commission (EC)
  • Project Code: 742654
  • Funding stream: H2020 | ERC | ERC-ADG
60 references, page 1 of 4

Abeles, A., Brendler, T., Austin, S.. Evidence of two levels of control of P1 oriR and host oriC replication origins by DNA adenine methylation. J. Bacteriol.. 1993; 175: 7801-7807 [OpenAIRE] [PubMed]

Aravind, L., Iyer, L.M.. The HARE-HTH and associated domains: novel modules in the coordination of epigenetic DNA and protein modifications. Cell Cycle. 2012; 11: 119-131 [OpenAIRE] [PubMed]

Asada, S., Goyama, S., Inoue, D., Shikata, S., Takeda, R., Fukushima, T., Yonezawa, T., Fujino, T., Hayashi, Y., Kawabata, K.C.. Mutant ASXL1 cooperates with BAP1 to promote myeloid leukaemogenesis. Nat. Commun.. 2018; 9: 2733 [OpenAIRE] [PubMed]

Au, K.G., Welsh, K., Modrich, P.. Initiation of methyl-directed mismatch repair. J. Biol. Chem.. 1992; 267: 12142-12148 [PubMed]

Balasubramani, A., Larjo, A., Bassein, J.A., Chang, X., Hastie, R.B., Togher, S.M., Lähdesmäki, H., Rao, A.. Cancer-associated ASXL1 mutations may act as gain-of-function mutations of the ASXL1-BAP1 complex. Nat. Commun.. 2015; 6: 7307 [OpenAIRE] [PubMed]

Bosselut, R.. Pleiotropic functions of H3K27Me3 demethylases in immune cell differentiation. Trends Immunol.. 2016; 37: 102-113 [OpenAIRE] [PubMed]

Boultwood, J., Perry, J., Pellagatti, A., Fernandez-Mercado, M., Fernandez-Santamaria, C., Calasanz, M.J., Larrayoz, M.J., Garcia-Delgado, M., Giagounidis, A., Malcovati, L.. Frequent mutation of the polycomb-associated gene ASXL1 in the myelodysplastic syndromes and in acute myeloid leukemia. Leukemia. 2010; 24: 1062-1065 [PubMed]

Bramswig, N.C., Lüdecke, H.J., Pettersson, M., Albrecht, B., Bernier, R.A., Cremer, K., Eichler, E.E., Falkenstein, D., Gerdts, J., Jansen, S.. Identification of new TRIP12 variants and detailed clinical evaluation of individuals with non-syndromic intellectual disability with or without autism. Hum. Genet.. 2017; 136: 179-192 [OpenAIRE] [PubMed]

Bryson, A.L., Hwang, Y., Sherrill-Mix, S., Wu, G.D., Lewis, J.D., Black, L., Clark, T.A., Bushman, F.D.. Covalent modification of bacteriophage T4 DNA inhibits CRISPR-Cas9. MBio. 2015; 6: e00648 [OpenAIRE] [PubMed]

Bujnicki, J.M., Feder, M., Radlinska, M., Blumenthal, R.M.. Structure prediction and phylogenetic analysis of a functionally diverse family of proteins homologous to the MT-A70 subunit of the human mRNA:m(6)A methyltransferase. J. Mol. Evol.. 2002; 55: 431-444 [OpenAIRE] [PubMed]

Cong, L., Ran, F.A., Cox, D., Lin, S., Barretto, R., Habib, N., Hsu, P.D., Wu, X., Jiang, W., Marraffini, L.A., Zhang, F.. Multiplex genome engineering using CRISPR/Cas systems. Science. 2013; 339: 819-823 [OpenAIRE] [PubMed]

Dey, A., Seshasayee, D., Noubade, R., French, D.M., Liu, J., Chaurushiya, M.S., Kirkpatrick, D.S., Pham, V.C., Lill, J.R., Bakalarski, C.E.. Loss of the tumor suppressor BAP1 causes myeloid transformation. Science. 2012; 337: 1541-1546 [OpenAIRE] [PubMed]

Dominissini, D., Moshitch-Moshkovitz, S., Schwartz, S., Salmon-Divon, M., Ungar, L., Osenberg, S., Cesarkas, K., Jacob-Hirsch, J., Amariglio, N., Kupiec, M.. Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq. Nature. 2012; 485: 201-206 [OpenAIRE] [PubMed]

Frickey, T., Lupas, A.. CLANS: a Java application for visualizing protein families based on pairwise similarity. Bioinformatics. 2004; 20: 3702-3704 [OpenAIRE] [PubMed]

Fu, Y., Luo, G.Z., Chen, K., Deng, X., Yu, M., Han, D., Hao, Z., Liu, J., Lu, X., Doré, L.C.. N6-methyldeoxyadenosine marks active transcription start sites in Chlamydomonas. Cell. 2015; 161: 879-892 [OpenAIRE] [PubMed]

60 references, page 1 of 4
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