publication . Article . 2018

Effect of botulinum toxin injection on length and force of the rectus femoris and triceps surae muscles during locomotion in patients with chronic hemiparesis (FOLOTOX).

Supiot, Anthony; Geiger, Maxime; Bensmail, Djamel; Aegerter, Phillippe; Pradon, Didier; Roche, Nicolas;
Open Access English
  • Published: 02 Aug 2018 Journal: BMC Neurology (issn: 1471-2377, Copyright policy)
  • Publisher: BMC
  • Country: France
Abstract
International audience; BACKGROUND: After stroke, spasticity of the rectus femoris (RF) and triceps surae (TS) muscles frequently alters the gait pattern. Knee flexion and ankle dorsiflexion in swing are often reduced, respectively called Stiff Knee Gait (SKG) and equinus. A preliminary uncontrolled study suggested that botulinum toxin type A (BTX-A) injections could improve muscle length and force generated during gait, improving inter-segmental coordination. The aim of this randomised controlled study is thus to evaluate changes in the length of the RF and TS muscles during gait 1 month after either BTX-A or placebo injection in patients with chronic stroke, S...
Subjects
free text keywords: Stroke, Botulinum toxin type A, Muscle length, Motion analysis, Gait, Neurology. Diseases of the nervous system, RC346-429, Study Protocol, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Clinical Neurology, General Medicine, medicine.disease, medicine, Hemiparesis, medicine.symptom, Gait analysis, Placebo, Physical therapy, medicine.medical_specialty, Spastic, Spasticity, Randomized controlled trial, law.invention, law, business.industry, business
61 references, page 1 of 5

1. Brandstater ME, Gowland C, Clark BM. Hemiplegic gait: analysis of temporal variables. Arch Phys Med Rehabil. 1983;64:583-7.

2. Olney SJ, Griffin MP, McBride ID. Temporal, kinematic, and kinetic variables related to gait speed in subjects with hemiplegia: a regression approach. Phys Ther. 1994;74:872-85. [OpenAIRE]

3. Pinzur MS, Sherman R, Dimonte-Levine P, Trimble J. Gait changes in adult onset hemiplegia. Am J Phys Med Rehabil. 1987;66:228-37.

4. Kerrigan DC, Gronley J, Perry J. Stiff-legged gait in spastic paresis. A study of quadriceps and hamstrings muscle activity. Am J Phys Med Rehabil. 1991; 70:294-300.

5. Pittock SJ, Moore AP, Hardiman O, Ehler E, Kovac M, Bojakowski J, et al. A Double-Blind Randomised Placebo-Controlled Evaluation of Three Doses of Botulinum Toxin Type A (Dysport<sup>®</sup>) in the Treatment of Spastic Equinovarus Deformity after Stroke. Cerebrovasc Dis. 2003;15:289-300.

6. Robertson JVG, Pradon D, Bensmail D, Fermanian C, Bussel B, Roche N. Relevance of botulinum toxin injection and nerve block of rectus femoris to kinematic and functional parameters of stiff knee gait in hemiplegic adults. Gait Posture. 2009;29:108-12.

7. Kerrigan DC, Roth RS, Riley PO. The modelling of adult spastic paretic stifflegged gait swing period based on actual kinematic data. Gait Posture. 1998;7:117-24.

8. Kim CM, Eng JJ. Magnitude and pattern of 3D kinematic and kinetic gait profiles in persons with stroke: relationship to walking speed. Gait Posture. 2004;20:140-6.

9. Knutsson E, Richards C. Different types of disturbed motor control in gait of hemiparetic patients. Brain J Neurol. 1979;102:405-30. [OpenAIRE]

10. Schantz EJ, Johnson EA. Properties and use of botulinum toxin and other microbial neurotoxins in medicine. Microbiol Rev. 1992;56:80-99.

11. Stoquart GG, Detrembleur C, Palumbo S, Deltombe T, Lejeune TM. Effect of Botulinum toxin injection in the rectus Femoris on stiff-knee gait in people with stroke: a prospective observational study. Arch Phys Med Rehabil. 2008; 89:56-61. [OpenAIRE]

12. Caty GD, Detrembleur C, Bleyenheuft C, Deltombe T, Lejeune TM. Effect of simultaneous Botulinum toxin injections into several muscles on impairment, activity, participation, and quality of life among stroke patients presenting with a stiff knee gait. Stroke. 2008;39:2803-8. [OpenAIRE]

13. Hutin E, Pradon D, Barbier F, Gracies J-M, Bussel B, Roche N. Lower limb coordination in Hemiparetic subjects: impact of Botulinum toxin injections into rectus Femoris. Neurorehabil Neural Repair. 2010;24:442-9.

14. Simon SR. Quantification of human motion: gait analysis-benefits and limitations to its application to clinical problems. J Biomech. 2004;37:1869-80.

15. Lampire N, Roche N, Carne P, Cheze L, Pradon D. Effect of botulinum toxin injection on length and lengthening velocity of rectus femoris during gait in hemiparetic patients. Clin Biomech Bristol Avon. 2013;28:164-70. [OpenAIRE]

61 references, page 1 of 5
Abstract
International audience; BACKGROUND: After stroke, spasticity of the rectus femoris (RF) and triceps surae (TS) muscles frequently alters the gait pattern. Knee flexion and ankle dorsiflexion in swing are often reduced, respectively called Stiff Knee Gait (SKG) and equinus. A preliminary uncontrolled study suggested that botulinum toxin type A (BTX-A) injections could improve muscle length and force generated during gait, improving inter-segmental coordination. The aim of this randomised controlled study is thus to evaluate changes in the length of the RF and TS muscles during gait 1 month after either BTX-A or placebo injection in patients with chronic stroke, S...
Subjects
free text keywords: Stroke, Botulinum toxin type A, Muscle length, Motion analysis, Gait, Neurology. Diseases of the nervous system, RC346-429, Study Protocol, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Clinical Neurology, General Medicine, medicine.disease, medicine, Hemiparesis, medicine.symptom, Gait analysis, Placebo, Physical therapy, medicine.medical_specialty, Spastic, Spasticity, Randomized controlled trial, law.invention, law, business.industry, business
61 references, page 1 of 5

1. Brandstater ME, Gowland C, Clark BM. Hemiplegic gait: analysis of temporal variables. Arch Phys Med Rehabil. 1983;64:583-7.

2. Olney SJ, Griffin MP, McBride ID. Temporal, kinematic, and kinetic variables related to gait speed in subjects with hemiplegia: a regression approach. Phys Ther. 1994;74:872-85. [OpenAIRE]

3. Pinzur MS, Sherman R, Dimonte-Levine P, Trimble J. Gait changes in adult onset hemiplegia. Am J Phys Med Rehabil. 1987;66:228-37.

4. Kerrigan DC, Gronley J, Perry J. Stiff-legged gait in spastic paresis. A study of quadriceps and hamstrings muscle activity. Am J Phys Med Rehabil. 1991; 70:294-300.

5. Pittock SJ, Moore AP, Hardiman O, Ehler E, Kovac M, Bojakowski J, et al. A Double-Blind Randomised Placebo-Controlled Evaluation of Three Doses of Botulinum Toxin Type A (Dysport<sup>®</sup>) in the Treatment of Spastic Equinovarus Deformity after Stroke. Cerebrovasc Dis. 2003;15:289-300.

6. Robertson JVG, Pradon D, Bensmail D, Fermanian C, Bussel B, Roche N. Relevance of botulinum toxin injection and nerve block of rectus femoris to kinematic and functional parameters of stiff knee gait in hemiplegic adults. Gait Posture. 2009;29:108-12.

7. Kerrigan DC, Roth RS, Riley PO. The modelling of adult spastic paretic stifflegged gait swing period based on actual kinematic data. Gait Posture. 1998;7:117-24.

8. Kim CM, Eng JJ. Magnitude and pattern of 3D kinematic and kinetic gait profiles in persons with stroke: relationship to walking speed. Gait Posture. 2004;20:140-6.

9. Knutsson E, Richards C. Different types of disturbed motor control in gait of hemiparetic patients. Brain J Neurol. 1979;102:405-30. [OpenAIRE]

10. Schantz EJ, Johnson EA. Properties and use of botulinum toxin and other microbial neurotoxins in medicine. Microbiol Rev. 1992;56:80-99.

11. Stoquart GG, Detrembleur C, Palumbo S, Deltombe T, Lejeune TM. Effect of Botulinum toxin injection in the rectus Femoris on stiff-knee gait in people with stroke: a prospective observational study. Arch Phys Med Rehabil. 2008; 89:56-61. [OpenAIRE]

12. Caty GD, Detrembleur C, Bleyenheuft C, Deltombe T, Lejeune TM. Effect of simultaneous Botulinum toxin injections into several muscles on impairment, activity, participation, and quality of life among stroke patients presenting with a stiff knee gait. Stroke. 2008;39:2803-8. [OpenAIRE]

13. Hutin E, Pradon D, Barbier F, Gracies J-M, Bussel B, Roche N. Lower limb coordination in Hemiparetic subjects: impact of Botulinum toxin injections into rectus Femoris. Neurorehabil Neural Repair. 2010;24:442-9.

14. Simon SR. Quantification of human motion: gait analysis-benefits and limitations to its application to clinical problems. J Biomech. 2004;37:1869-80.

15. Lampire N, Roche N, Carne P, Cheze L, Pradon D. Effect of botulinum toxin injection on length and lengthening velocity of rectus femoris during gait in hemiparetic patients. Clin Biomech Bristol Avon. 2013;28:164-70. [OpenAIRE]

61 references, page 1 of 5
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