publication . Article . 2018

Evidence for Sprouting of Dopamine and Serotonin Axons in the Pallidum of Parkinsonian Monkeys.

Dave Gagnon; Lara Eid; Dymka Coudé; Carl Whissel; Thérèse Di Paolo; André Parent; Martin Parent;
Open Access English
  • Published: 01 May 2018
  • Publisher: Frontiers Research Foundation
  • Country: France
Abstract
This light and electron microscopic immunohistochemical quantitative study aimed at determining the state of the dopamine (DA) and serotonin (5-HT) innervations of the internal (GPi) and external (GPe) segments of the pallidum in cynomolgus monkeys (Macaca fascicularis) rendered parkinsonian by systemic injections of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). In contrast to the prominent DA denervation of striatum, the GPi in MPTP monkeys was found to be markedly enriched in DA (TH+) axon varicosities. The posterior sensorimotor region of this major output structure of the basal ganglia was about 8 times more intensely innervated in MPTP monkeys (0.71 ...
Subjects
Medical Subject Headings: nervous system
free text keywords: Basal ganglia, Globus pallidus, Parkinson’s disease, MPTP-intoxicated monkeys, Non-human primates, Neurodegenerative diseases, Noyaux gris centraux, Pallidum, Système nerveux central -- Dégénérescence -- Modèles animaux, Maladie de Parkinson -- Modèles animaux, Macaque crabier, Singes (Animaux de laboratoire), Méthylphényltétrahydropyridine, Dopamine, Sérotonine, Axones (Biologie), Neuroscience, Original Research, Parkinson's disease, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Human anatomy, QM1-695, Anatomy, Cellular and Molecular Neuroscience, Neuroscience (miscellaneous)
Related Organizations
Funded by
CIHR
Project
  • Funder: Canadian Institutes of Health Research (CIHR)
87 references, page 1 of 6

Arai R.Karasawa N.Geffard M.Nagatsu I. (1995). L-DOPA is converted to dopamine in serotonergic fibers of the striatum of the rat: a double-labeling immunofluorescence study. Neurosci. Lett. 195, 195–198. 10.1016/0304-3940(95)11817-G 8584208 [OpenAIRE] [PubMed] [DOI]

Arai R.Karasawa N.Geffard M.Nagatsu T.Nagatsu I. (1994). Immunohistochemical evidence that central serotonin neurons produce dopamine from exogenous L-DOPA in the rat, with reference to the involvement of aromatic L-amino acid decarboxylase. Brain Res. 667, 295–299. 10.1016/0006-8993(94)91511-3 7697371 [OpenAIRE] [PubMed] [DOI]

Ballanger B.Beaudoin-Gobert M.Neumane S.Epinat J.Metereau E.Duperrier S.. (2016). Imaging dopamine and serotonin systems on MPTP monkeys: a longitudinal PET investigation of compensatory mechanisms. J. Neurosci.36, 1577–1589. 10.1523/JNEUROSCI.2010-15.2016 26843639 [OpenAIRE] [PubMed] [DOI]

Beaudet A.Sotelo C. (1981). Synaptic remodeling of serotonin axon terminals in rat agranular cerebellum. Brain Res. 206, 305–329. 10.1016/0006-8993(81)90534-5 7214137 [OpenAIRE] [PubMed] [DOI]

Bernheimer H.Birkmayer W.Hornykiewicz O.Jellinger K.Seitelberger F. (1973). Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlations. J. Neurol. Sci. 20, 415–455. 10.1016/0022-510X(73)90175-5 4272516 [OpenAIRE] [PubMed] [DOI]

Bez F.Francardo V.Cenci M. A. (2016). Dramatic differences in susceptibility to l-DOPA-induced dyskinesia between mice that are aged before or after a nigrostriatal dopamine lesion. Neurobiol. Dis. 94, 213–225. 10.1016/j.nbd.2016.06.005 27312773 [OpenAIRE] [PubMed] [DOI]

Bezard E.Dovero S.Prunier C.Ravenscroft P.Chalon S.Guilloteau D.. (2001). Relationship between the appearance of symptoms and the level of nigrostriatal degeneration in a progressive 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned macaque model of Parkinson's disease. J. Neurosci.21, 6853–6861. 10.1523/JNEUROSCI.21-17-06853.2001 11517273 [OpenAIRE] [PubMed] [DOI]

Bolam J. P.Pissadaki E. K. (2012). Living on the edge with too many mouths to feed: why dopamine neurons die. Mov. Disord. 27, 1478–1483. 10.1002/mds.25135 23008164 [OpenAIRE] [PubMed] [DOI]

Bonaventure P.Voorn P.Luyten W. H.Jurzak M.Schotte A.Leysen J. E. (1998). Detailed mapping of serotonin 5-HT1B and 5-HT1D receptor messenger RNA and ligand binding sites in guinea-pig brain and trigeminal ganglion: clues for function. Neuroscience 82, 469–484. 10.1016/S0306-4522(97)00302-3 9466454 [PubMed] [DOI]

Bourque M.Morissette M.Di Paolo T. (2015). Neuroprotection in Parkinsonian-treated mice via estrogen receptor alpha activation requires G protein-coupled estrogen receptor 1. Neuropharmacology 95, 343–352. 10.1016/j.neuropharm.2015.04.006 25892506 [OpenAIRE] [PubMed] [DOI]

Bowden D. M.Martin R. F. (2000). Primate Brain Maps: Structure of the Macaque Brain. Amsterdam: Elsevier.

Carta M.Carlsson T.Kirik D.Björklund A. (2007). Dopamine released from 5-HT terminals is the cause of L-DOPA-induced dyskinesia in parkinsonian rats. Brain 130, 1819–1833. 10.1093/brain/awm082 17452372 [OpenAIRE] [PubMed] [DOI]

Carta M.Carlsson T.Munoz A.Kirik D.Björklund A. (2008). Involvement of the serotonin system in L-dopa-induced dyskinesias. Parkinsonism Relat. Disord. 14 Suppl. 2, S154–S158. 10.1016/j.parkreldis.2008.04.021 [OpenAIRE] [DOI]

Carta M.Tronci E. (2014). Serotonin system implication in l-DOPA-induced dyskinesia: from animal models to clinical investigations. Front. Neurol. 5:78. 10.3389/fneur.2014.00078 24904522 [OpenAIRE] [PubMed] [DOI]

Castro M. E.Pascual J.Romón T.Berciano J.Figols J.Pazos A. (1998). 5-HT1B receptor binding in degenerative movement disorders. Brain Res. 790, 323–328. 10.1016/S0006-8993(97)01566-7 9593971 [PubMed] [DOI]

87 references, page 1 of 6
Abstract
This light and electron microscopic immunohistochemical quantitative study aimed at determining the state of the dopamine (DA) and serotonin (5-HT) innervations of the internal (GPi) and external (GPe) segments of the pallidum in cynomolgus monkeys (Macaca fascicularis) rendered parkinsonian by systemic injections of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). In contrast to the prominent DA denervation of striatum, the GPi in MPTP monkeys was found to be markedly enriched in DA (TH+) axon varicosities. The posterior sensorimotor region of this major output structure of the basal ganglia was about 8 times more intensely innervated in MPTP monkeys (0.71 ...
Subjects
Medical Subject Headings: nervous system
free text keywords: Basal ganglia, Globus pallidus, Parkinson’s disease, MPTP-intoxicated monkeys, Non-human primates, Neurodegenerative diseases, Noyaux gris centraux, Pallidum, Système nerveux central -- Dégénérescence -- Modèles animaux, Maladie de Parkinson -- Modèles animaux, Macaque crabier, Singes (Animaux de laboratoire), Méthylphényltétrahydropyridine, Dopamine, Sérotonine, Axones (Biologie), Neuroscience, Original Research, Parkinson's disease, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Human anatomy, QM1-695, Anatomy, Cellular and Molecular Neuroscience, Neuroscience (miscellaneous)
Related Organizations
Funded by
CIHR
Project
  • Funder: Canadian Institutes of Health Research (CIHR)
87 references, page 1 of 6

Arai R.Karasawa N.Geffard M.Nagatsu I. (1995). L-DOPA is converted to dopamine in serotonergic fibers of the striatum of the rat: a double-labeling immunofluorescence study. Neurosci. Lett. 195, 195–198. 10.1016/0304-3940(95)11817-G 8584208 [OpenAIRE] [PubMed] [DOI]

Arai R.Karasawa N.Geffard M.Nagatsu T.Nagatsu I. (1994). Immunohistochemical evidence that central serotonin neurons produce dopamine from exogenous L-DOPA in the rat, with reference to the involvement of aromatic L-amino acid decarboxylase. Brain Res. 667, 295–299. 10.1016/0006-8993(94)91511-3 7697371 [OpenAIRE] [PubMed] [DOI]

Ballanger B.Beaudoin-Gobert M.Neumane S.Epinat J.Metereau E.Duperrier S.. (2016). Imaging dopamine and serotonin systems on MPTP monkeys: a longitudinal PET investigation of compensatory mechanisms. J. Neurosci.36, 1577–1589. 10.1523/JNEUROSCI.2010-15.2016 26843639 [OpenAIRE] [PubMed] [DOI]

Beaudet A.Sotelo C. (1981). Synaptic remodeling of serotonin axon terminals in rat agranular cerebellum. Brain Res. 206, 305–329. 10.1016/0006-8993(81)90534-5 7214137 [OpenAIRE] [PubMed] [DOI]

Bernheimer H.Birkmayer W.Hornykiewicz O.Jellinger K.Seitelberger F. (1973). Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlations. J. Neurol. Sci. 20, 415–455. 10.1016/0022-510X(73)90175-5 4272516 [OpenAIRE] [PubMed] [DOI]

Bez F.Francardo V.Cenci M. A. (2016). Dramatic differences in susceptibility to l-DOPA-induced dyskinesia between mice that are aged before or after a nigrostriatal dopamine lesion. Neurobiol. Dis. 94, 213–225. 10.1016/j.nbd.2016.06.005 27312773 [OpenAIRE] [PubMed] [DOI]

Bezard E.Dovero S.Prunier C.Ravenscroft P.Chalon S.Guilloteau D.. (2001). Relationship between the appearance of symptoms and the level of nigrostriatal degeneration in a progressive 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned macaque model of Parkinson's disease. J. Neurosci.21, 6853–6861. 10.1523/JNEUROSCI.21-17-06853.2001 11517273 [OpenAIRE] [PubMed] [DOI]

Bolam J. P.Pissadaki E. K. (2012). Living on the edge with too many mouths to feed: why dopamine neurons die. Mov. Disord. 27, 1478–1483. 10.1002/mds.25135 23008164 [OpenAIRE] [PubMed] [DOI]

Bonaventure P.Voorn P.Luyten W. H.Jurzak M.Schotte A.Leysen J. E. (1998). Detailed mapping of serotonin 5-HT1B and 5-HT1D receptor messenger RNA and ligand binding sites in guinea-pig brain and trigeminal ganglion: clues for function. Neuroscience 82, 469–484. 10.1016/S0306-4522(97)00302-3 9466454 [PubMed] [DOI]

Bourque M.Morissette M.Di Paolo T. (2015). Neuroprotection in Parkinsonian-treated mice via estrogen receptor alpha activation requires G protein-coupled estrogen receptor 1. Neuropharmacology 95, 343–352. 10.1016/j.neuropharm.2015.04.006 25892506 [OpenAIRE] [PubMed] [DOI]

Bowden D. M.Martin R. F. (2000). Primate Brain Maps: Structure of the Macaque Brain. Amsterdam: Elsevier.

Carta M.Carlsson T.Kirik D.Björklund A. (2007). Dopamine released from 5-HT terminals is the cause of L-DOPA-induced dyskinesia in parkinsonian rats. Brain 130, 1819–1833. 10.1093/brain/awm082 17452372 [OpenAIRE] [PubMed] [DOI]

Carta M.Carlsson T.Munoz A.Kirik D.Björklund A. (2008). Involvement of the serotonin system in L-dopa-induced dyskinesias. Parkinsonism Relat. Disord. 14 Suppl. 2, S154–S158. 10.1016/j.parkreldis.2008.04.021 [OpenAIRE] [DOI]

Carta M.Tronci E. (2014). Serotonin system implication in l-DOPA-induced dyskinesia: from animal models to clinical investigations. Front. Neurol. 5:78. 10.3389/fneur.2014.00078 24904522 [OpenAIRE] [PubMed] [DOI]

Castro M. E.Pascual J.Romón T.Berciano J.Figols J.Pazos A. (1998). 5-HT1B receptor binding in degenerative movement disorders. Brain Res. 790, 323–328. 10.1016/S0006-8993(97)01566-7 9593971 [PubMed] [DOI]

87 references, page 1 of 6
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