publication . Article . Other literature type . 2006

Variant Creutzfeldt-Jakob disease: prion protein genotype analysis of positive appendix tissue samples from a retrospective prevalence study

Ironside, James W; Bishop, Matthew T; Connolly, Kelly; Hegazy, Doha; Lowrie, Suzanne; Le Grice, Margaret; Ritchie, Diane L; McCardle, Linda M; Hilton, David A;
Open Access
  • Published: 20 May 2006 Journal: Yearbook of Pediatrics, volume 2,008, pages 359-361 (issn: 0084-3954, Copyright policy)
  • Publisher: Elsevier BV
  • Country: United Kingdom
Abstract
Objective To perform prion protein gene (PRNP) codon 129 analysis in DNA extracted from appendix tissue samples that had tested positive for disease associated prion protein.<br/><br/>Design Reanalysis of positive cases identified in a retrospective anonymised unlinked prevalence study of variant Creutzfeldt-Jakob disease (vCJD) in the United Kingdom.<br/><br/>Study samples Three positive appendix tissue samples out of 12 674 samples of appendix and tonsil tested for disease associated prion protein. The patients from whom these samples were obtained were aged 20-29 years at the time of surgery, which took place in 1996-9.<br/><br/>Setting Pathology departments ...
Subjects
Medical Subject Headings: mental disordersnervous system diseases
free text keywords: Variant Creutzfeldt–Jakob disease, Appendix, medicine.anatomical_structure, medicine, Virology, Pediatrics, medicine.medical_specialty, Dermatology, Genotype Analysis, business.industry, business, Methionine, chemistry.chemical_compound, chemistry, Incubation period, Locus (genetics), Heterozygote advantage, Tonsil, Pathology, PRNP, Genotype, Asymptomatic, medicine.symptom, Corrections, Research
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Europe PubMed Central
Other literature type . 2006
Europe PubMed Central
Other literature type . 2006
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