publication . Article . Other literature type . 2008

Genome-wide association study provides evidence for a breast cancer risk locus at 6q22.33

Gold, B.; Kirchhoff, T.; Stefanov, S.; Lautenberger, J.; Viale, A.; Garber, J.; Friedman, E.; Narod, S.; Olshen, A. B.; Gregersen, P.; ...
Open Access
  • Published: 07 Mar 2008 Journal: Proceedings of the National Academy of Sciences, volume 105, pages 4,340-4,345 (issn: 0027-8424, eissn: 1091-6490, Copyright policy)
  • Publisher: Proceedings of the National Academy of Sciences
Abstract
We performed a three-phase genome-wide association study (GWAS) using cases and controls from a genetically isolated population, Ashkenazi Jews (AJ), to identify loci associated with breast cancer risk. In the first phase, we compared allele frequencies of 150,080 SNPs in 249 high-risk, BRCA1/2 mutation-negative AJ familial cases and 299 cancer-free AJ controls using χ2 and the Cochran–Armitage trend tests. In the second phase, we genotyped 343 SNPs from 123 regions most significantly associated from stage 1, including 4 SNPs from the FGFR2 region, in 950 consecutive AJ breast cancer cases and 979 age-matched AJ controls. We replicated major associations in a th...
Subjects
free text keywords: Multidisciplinary, Allele frequency, Haplotype, Candidate gene, Single-nucleotide polymorphism, TOX3, Locus (genetics), Genetics, Genome-wide association study, Biology, Population, education.field_of_study, education, Biological Sciences
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publication . Article . Other literature type . 2008

Genome-wide association study provides evidence for a breast cancer risk locus at 6q22.33

Gold, B.; Kirchhoff, T.; Stefanov, S.; Lautenberger, J.; Viale, A.; Garber, J.; Friedman, E.; Narod, S.; Olshen, A. B.; Gregersen, P.; ...