publication . Other literature type . Article . 2008

The Population Genetics of Using Homing Endonuclease Genes in Vector and Pest Management

Deredec, A; Burt, A; Godfray, HC;
  • Published: 01 Aug 2008
  • Publisher: Genetics Society of America
  • Country: United Kingdom
Abstract
Homing endonuclease genes (HEGs) encode proteins that in the heterozygous state cause double-strand breaks in the homologous chromosome at the precise position opposite the HEG. If the double-strand break is repaired using the homologous chromosome, the HEG becomes homozygous, and this represents a powerful genetic drive mechanism that might be used as a tool in managing vector or pest populations. HEGs may be used to decrease population fitness to drive down population densities (possibly causing local extinction) or, in disease vectors, to knock out a gene required for pathogen transmission. The relative advantages of HEGs that target viability or fecundity, t...
Subjects
free text keywords: HEG, population genetic engineering, model, population control, [SDV]Life Sciences [q-bio], [SDE]Environmental Sciences, Investigations, Genetics, Population, education.field_of_study, education, X chromosome, Gene drive, Homologous chromosome, Homing endonuclease, biology.protein, biology, Homing (biology), Mutant, Y chromosome
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