publication . Other literature type . Article . 2009

Genome-wide expression profiling of in vivo- derived bloodstream parasite stages and dynamic analysis of mRNA alterations during synchronous differentiation in Trypanosoma brucei

Alasdair Ivens; Peter Ghazal; Professor Keith Matthews FRS FMedSci FRSE;
Open Access
  • Published: 01 Sep 2009
  • Publisher: Springer Science and Business Media LLC
  • Country: United Kingdom
Abstract
<p>Abstract</p> <p>Background</p> <p>Trypanosomes undergo extensive developmental changes during their complex life cycle. Crucial among these is the transition between slender and stumpy bloodstream forms and, thereafter, the differentiation from stumpy to tsetse-midgut procyclic forms. These developmental events are highly regulated, temporally reproducible and accompanied by expression changes mediated almost exclusively at the post-transcriptional level.</p> <p>Results</p> <p>In this study we have examined, by whole-genome microarray analysis, the mRNA abundance of genes in slender and stumpy forms of <it>T.brucei </it>AnTat1.1 cells, and also during their s...
Subjects
free text keywords: /dk/atira/pure/subjectarea/asjc/1300/1311, Genetics, /dk/atira/pure/subjectarea/asjc/1300/1305, Biotechnology, Cell-cycle progression, African trypanosomes, Life-cycle, Gene-expression, Developmental regulation, Procyclic forms, CCCH Protein, Transcriptional program, Histone deacetylases, Leishmania, QH426 Genetics, QH426, Research Article, TP248.13-248.65, QH426-470
Related Organizations
74 references, page 1 of 5

Cho, RJ, Campbell, MJ, Winzeler, EA, Steinmetz, L, Conway, A, Wodicka, L, Wolfsberg, TG, Gabrielian, AE, Landsman, D, Lockhart, DJ. A genome-wide transcriptional analysis of the mitotic cell cycle. Mol Cell. 1998; 2: 65-73 [OpenAIRE] [PubMed] [DOI]

Chu, S, DeRisi, J, Eisen, M, Mulholland, J, Botstein, D, Brown, PO, Herskowitz, I. The transcriptional program of sporulation in budding yeast. Science. 1998; 282: 699-705 [OpenAIRE] [PubMed] [DOI]

McCarroll, SA, Murphy, CT, Zou, S, Pletcher, SD, Chin, CS, Jan, YN, Kenyon, C, Bargmann, CI, Li, H. Comparing genomic expression patterns across species identifies shared transcriptional profile in aging. Nat Genet. 2004; 36: 197-204 [OpenAIRE] [PubMed] [DOI]

White, KP, Rifkin, SA, Hurban, P, Hogness, DS. Microarray analysis of Drosophila development during metamorphosis. Science. 1999; 286: 2179-2184 [OpenAIRE] [PubMed] [DOI]

Hall, N, Karras, M, Raine, JD, Carlton, JM, Kooij, TW, Berriman, M, Florens, L, Janssen, CS, Pain, A, Christophides, GK. A comprehensive survey of the Plasmodium life cycle by genomic, transcriptomic, and proteomic analyses. Science. 2005; 307: 82-86 [OpenAIRE] [PubMed] [DOI]

Kasuga, T, Townsend, JP, Tian, C, Gilbert, LB, Mannhaupt, G, Taylor, JW, Glass, NL. Long-oligomer microarray profiling in Neurospora crassa reveals the transcriptional program underlying biochemical and physiological events of conidial germination. Nucleic Acids Res. 2005; 33: 6469-6485 [OpenAIRE] [PubMed] [DOI]

Konstantinopoulos, PA, Spentzos, D, Cannistra, SA. Gene-expression profiling in epithelial ovarian cancer. Nat Clin Pract Oncol. 2008; 5: 577-587 [OpenAIRE] [PubMed] [DOI]

Farber, CR, Lusis, AJ. Integrating global gene expression analysis and genetics. Adv Genetics. 2008; 60: 571-601 [OpenAIRE]

Futcher, B. Transcriptional regulatory networks and the yeast cell cycle. Curr Op Cell Biol. 2002; 14: 676-683 [OpenAIRE] [PubMed] [DOI]

Bozdech, Z, Llinas, M, Pulliam, BL, Wong, ED, Zhu, J, DeRisi, JL. The transcriptome of the intraerythrocytic developmental cycle of Plasmodium falciparum. PLoS Biol. 2003; 1: E5 [OpenAIRE] [PubMed] [DOI]

Bozdech, Z, Zhu, J, Joachimiak, MP, Cohen, FE, Pulliam, B, DeRisi, JL. Expression profiling of the schizont and trophozoite stages of Plasmodium falciparum with a long-oligonucleotide microarray. Genome Biol. 2003; 4: R9 [OpenAIRE] [PubMed] [DOI]

Barrett, MP, Burchmore, RJ, Stich, A, Lazzari, JO, Frasch, AC, Cazzulo, JJ, Krishna, S. The trypanosomiases. Lancet. 2003; 362: 1469-1480 [OpenAIRE] [PubMed] [DOI]

Sogin, ML, Elwood, HJ, Gunderson, JH. Evolutionary diversity of eukaryotic small-subunit rRNA genes. Proc Natl Acad Sci USA. 1986; 83: 1383-1387 [OpenAIRE] [PubMed] [DOI]

Haile, S, Papadopoulou, B. Developmental regulation of gene expression in trypanosomatid parasitic protozoa. Curr Op Microbiol. 2007; 10: 569-577 [OpenAIRE] [DOI]

Ivens, AC, Peacock, CS, Worthey, EA, Murphy, L, Aggarwal, G, Berriman, M, Sisk, E, Rajandream, MA, Adlem, E, Aert, R. The genome of the kinetoplastid parasite, Leishmania major. Science. 2005; 309: 436-442 [OpenAIRE] [PubMed] [DOI]

74 references, page 1 of 5
Abstract
<p>Abstract</p> <p>Background</p> <p>Trypanosomes undergo extensive developmental changes during their complex life cycle. Crucial among these is the transition between slender and stumpy bloodstream forms and, thereafter, the differentiation from stumpy to tsetse-midgut procyclic forms. These developmental events are highly regulated, temporally reproducible and accompanied by expression changes mediated almost exclusively at the post-transcriptional level.</p> <p>Results</p> <p>In this study we have examined, by whole-genome microarray analysis, the mRNA abundance of genes in slender and stumpy forms of <it>T.brucei </it>AnTat1.1 cells, and also during their s...
Subjects
free text keywords: /dk/atira/pure/subjectarea/asjc/1300/1311, Genetics, /dk/atira/pure/subjectarea/asjc/1300/1305, Biotechnology, Cell-cycle progression, African trypanosomes, Life-cycle, Gene-expression, Developmental regulation, Procyclic forms, CCCH Protein, Transcriptional program, Histone deacetylases, Leishmania, QH426 Genetics, QH426, Research Article, TP248.13-248.65, QH426-470
Related Organizations
74 references, page 1 of 5

Cho, RJ, Campbell, MJ, Winzeler, EA, Steinmetz, L, Conway, A, Wodicka, L, Wolfsberg, TG, Gabrielian, AE, Landsman, D, Lockhart, DJ. A genome-wide transcriptional analysis of the mitotic cell cycle. Mol Cell. 1998; 2: 65-73 [OpenAIRE] [PubMed] [DOI]

Chu, S, DeRisi, J, Eisen, M, Mulholland, J, Botstein, D, Brown, PO, Herskowitz, I. The transcriptional program of sporulation in budding yeast. Science. 1998; 282: 699-705 [OpenAIRE] [PubMed] [DOI]

McCarroll, SA, Murphy, CT, Zou, S, Pletcher, SD, Chin, CS, Jan, YN, Kenyon, C, Bargmann, CI, Li, H. Comparing genomic expression patterns across species identifies shared transcriptional profile in aging. Nat Genet. 2004; 36: 197-204 [OpenAIRE] [PubMed] [DOI]

White, KP, Rifkin, SA, Hurban, P, Hogness, DS. Microarray analysis of Drosophila development during metamorphosis. Science. 1999; 286: 2179-2184 [OpenAIRE] [PubMed] [DOI]

Hall, N, Karras, M, Raine, JD, Carlton, JM, Kooij, TW, Berriman, M, Florens, L, Janssen, CS, Pain, A, Christophides, GK. A comprehensive survey of the Plasmodium life cycle by genomic, transcriptomic, and proteomic analyses. Science. 2005; 307: 82-86 [OpenAIRE] [PubMed] [DOI]

Kasuga, T, Townsend, JP, Tian, C, Gilbert, LB, Mannhaupt, G, Taylor, JW, Glass, NL. Long-oligomer microarray profiling in Neurospora crassa reveals the transcriptional program underlying biochemical and physiological events of conidial germination. Nucleic Acids Res. 2005; 33: 6469-6485 [OpenAIRE] [PubMed] [DOI]

Konstantinopoulos, PA, Spentzos, D, Cannistra, SA. Gene-expression profiling in epithelial ovarian cancer. Nat Clin Pract Oncol. 2008; 5: 577-587 [OpenAIRE] [PubMed] [DOI]

Farber, CR, Lusis, AJ. Integrating global gene expression analysis and genetics. Adv Genetics. 2008; 60: 571-601 [OpenAIRE]

Futcher, B. Transcriptional regulatory networks and the yeast cell cycle. Curr Op Cell Biol. 2002; 14: 676-683 [OpenAIRE] [PubMed] [DOI]

Bozdech, Z, Llinas, M, Pulliam, BL, Wong, ED, Zhu, J, DeRisi, JL. The transcriptome of the intraerythrocytic developmental cycle of Plasmodium falciparum. PLoS Biol. 2003; 1: E5 [OpenAIRE] [PubMed] [DOI]

Bozdech, Z, Zhu, J, Joachimiak, MP, Cohen, FE, Pulliam, B, DeRisi, JL. Expression profiling of the schizont and trophozoite stages of Plasmodium falciparum with a long-oligonucleotide microarray. Genome Biol. 2003; 4: R9 [OpenAIRE] [PubMed] [DOI]

Barrett, MP, Burchmore, RJ, Stich, A, Lazzari, JO, Frasch, AC, Cazzulo, JJ, Krishna, S. The trypanosomiases. Lancet. 2003; 362: 1469-1480 [OpenAIRE] [PubMed] [DOI]

Sogin, ML, Elwood, HJ, Gunderson, JH. Evolutionary diversity of eukaryotic small-subunit rRNA genes. Proc Natl Acad Sci USA. 1986; 83: 1383-1387 [OpenAIRE] [PubMed] [DOI]

Haile, S, Papadopoulou, B. Developmental regulation of gene expression in trypanosomatid parasitic protozoa. Curr Op Microbiol. 2007; 10: 569-577 [OpenAIRE] [DOI]

Ivens, AC, Peacock, CS, Worthey, EA, Murphy, L, Aggarwal, G, Berriman, M, Sisk, E, Rajandream, MA, Adlem, E, Aert, R. The genome of the kinetoplastid parasite, Leishmania major. Science. 2005; 309: 436-442 [OpenAIRE] [PubMed] [DOI]

74 references, page 1 of 5
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