publication . Article . Other literature type . 2011

Disease progression model for cognitive deterioration from Alzheimer's Disease Neuroimaging Initiative database

Ito, Kaori; Corrigan, Brian; Zhao, Qinying; French, Jonathan; Miller, Raymond; Soares, Holly; Katz, Elyse; Nicholas, Timothy; Billing, Bill; Anziano, Richard; ...
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  • Published: 01 Mar 2011 Journal: Alzheimer's & Dementia, volume 7, pages 151-160 (issn: 1552-5260, Copyright policy)
  • Publisher: Wiley
Abstract
Abstract Background A mathematical model was developed to describe the longitudinal response in Alzheimer's Disease Assessment Scale-cognitive (ADAS-cog) obtained from the Alzheimer's Disease Neuroimaging Initiative. Methods The model was fit to the longitudinal ADAS-cog scores from 817 patients. Risk factors (age, apolipoprotein ɛ4 [ APOE ɛ4] genotype, gender, family history of AD, years of education) and baseline severity were tested as covariates. Results Rate of disease progression increased with baseline severity. Age, APOE ɛ4 genotype, and gender were identified as potential covariates influencing disease progression. The rate of disease progression in pat...
Subjects
free text keywords: Health Policy, Developmental Neuroscience, Epidemiology, Cellular and Molecular Neuroscience, Geriatrics and Gerontology, Psychiatry and Mental health, Clinical Neurology, Psychiatry, medicine.medical_specialty, medicine, Alzheimer's Disease Neuroimaging Initiative, Apolipoprotein E, Disease, Neuroimaging, Gerontology, Natural history, Family history, Genotype, Diabetes mellitus, medicine.disease, Internal medicine, Psychology
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