publication . Article . 2011

The Cell Cycle Regulated Transcriptome of Trypanosoma brucei

Stuart Archer; Christine Clayton;
Open Access English
  • Published: 01 Mar 2011 Journal: PLoS ONE (issn: 1932-6203, Copyright policy)
  • Publisher: Public Library of Science (PLoS)
Abstract
Progression of the eukaryotic cell cycle requires the regulation of hundreds of genes to ensure that they are expressed at the required times. Integral to cell cycle progression in yeast and animal cells are temporally controlled, progressive waves of transcription mediated by cell cycle-regulated transcription factors. However, in the kinetoplastids, a group of early-branching eukaryotes including many important pathogens, transcriptional regulation is almost completely absent, raising questions about the extent of cell-cycle regulation in these organisms and the mechanisms whereby regulation is achieved. Here, we analyse gene expression over the Trypanosoma br...
Subjects
free text keywords: Medicine, R, Science, Q, Research Article, Biology, Computational Biology, Molecular Genetics, Gene Regulation, Microbiology, Protozoology, Parastic Protozoans, Trypanosoma, Molecular Cell Biology, Gene Expression, General Biochemistry, Genetics and Molecular Biology, General Agricultural and Biological Sciences, General Medicine
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65 references, page 1 of 5

Simon, I, Barnett, J, Hannett, N, Harbison, CT, Rinaldi, NJ. Serial regulation of transcriptional regulators in the yeast cell cycle.. Cell. 2001; 106: 697-708 [OpenAIRE] [PubMed]

Vaughan, PS, van der Meijden, CM, Aziz, F, Harada, H, Taniguchi, T. Cell cycle regulation of histone H4 gene transcription requires the oncogenic factor IRF-2.. J Biol Chem. 1998; 273: 194-199 [PubMed]

Harris, ME, Bohni, R, Schneiderman, MH, Ramamurthy, L, Schumperli, D. Regulation of histone mRNA in the unperturbed cell cycle: evidence suggesting control at two posttranscriptional steps.. Mol Cell Biol. 1991; 11: 2416-2424 [OpenAIRE] [PubMed]

Van Den Abbeele, J, Claes, Y, van Bockstaele, D, Le Ray, D, Coosemans, M. Trypanosoma brucei spp. development in the tsetse fly: characterization of the post-mesocyclic stages in the foregut and proboscis.. Parasitology. 1999; 118 (Pt 5): 469-478 [PubMed]

Clayton, CE. Life without transcriptional control? From fly to man and back again.. Embo J. 2002; 21: 1881-1888 [OpenAIRE] [PubMed]

Kabani, S, Fenn, K, Ross, A, Ivens, A, Smith, TK. Genome-wide expression profiling of in vivo-derived bloodstream parasite stages and dynamic analysis of mRNA alterations during synchronous differentiation in Trypanosoma brucei.. BMC Genomics. 2009; 10: 427 [OpenAIRE] [PubMed]

Queiroz, R, Benz, C, Fellenberg, K, Hoheisel, JD, Clayton, C. Transcriptome analysis of differentiating trypanosomes reveals the existence of multiple post-transcriptional regulons.. BMC Genomics. 2009; 10: 495 [OpenAIRE] [PubMed]

Akopyants, NS, Matlib, RS, Bukanova, EN, Smeds, MR, Brownstein, BH. Expression profiling using random genomic DNA microarrays identifies differentially expressed genes associated with three major developmental stages of the protozoan parasite Leishmania major.. Mol Biochem Parasitol. 2004; 136: 71-86 [OpenAIRE] [PubMed]

McKean, PG. Coordination of cell cycle and cytokinesis in Trypanosoma brucei.. Curr Opin Microbiol. 2003; 6: 600-607 [PubMed]

Ho, HH, He, CY, de Graffenried, CL, Murrells, LJ, Warren, G. Ordered assembly of the duplicating Golgi in Trypanosoma brucei.. Proc Natl Acad Sci U S A. 2006; 103: 7676-7681 [OpenAIRE] [PubMed]

Hammarton, TC. Cell cycle regulation in Trypanosoma brucei.. Mol Biochem Parasitol. 2007; 153: 1-8 [OpenAIRE] [PubMed]

Pasion, SG, Hines, JC, Ou, X, Mahmood, R, Ray, DS. Sequences within the 5′ untranslated region regulate the levels of a kinetoplast DNA topoisomerase mRNA during the cell cycle.. Mol Cell Biol. 1996; 16: 6724-6735 [OpenAIRE] [PubMed]

Mahmood, R, Mittra, B, Hines, JC, Ray, DS. Characterization of the Crithidia fasciculata mRNA cycling sequence binding proteins.. Mol Cell Biol. 2001; 21: 4453-4459 [OpenAIRE] [PubMed]

Mittra, B, Sinha, KM, Hines, JC, Ray, DS. Presence of multiple mRNA cycling sequence element-binding proteins in Crithidia fasciculata.. J Biol Chem. 2003; 278: 26564-26571 [OpenAIRE] [PubMed]

Mittra, B, Ray, DS. Presence of a poly(A) binding protein and two proteins with cell cycle-dependent phosphorylation in Crithidia fasciculata mRNA cycling sequence binding protein II.. Eukaryot Cell. 2004; 3: 1185-1197 [OpenAIRE] [PubMed]

65 references, page 1 of 5
Abstract
Progression of the eukaryotic cell cycle requires the regulation of hundreds of genes to ensure that they are expressed at the required times. Integral to cell cycle progression in yeast and animal cells are temporally controlled, progressive waves of transcription mediated by cell cycle-regulated transcription factors. However, in the kinetoplastids, a group of early-branching eukaryotes including many important pathogens, transcriptional regulation is almost completely absent, raising questions about the extent of cell-cycle regulation in these organisms and the mechanisms whereby regulation is achieved. Here, we analyse gene expression over the Trypanosoma br...
Subjects
free text keywords: Medicine, R, Science, Q, Research Article, Biology, Computational Biology, Molecular Genetics, Gene Regulation, Microbiology, Protozoology, Parastic Protozoans, Trypanosoma, Molecular Cell Biology, Gene Expression, General Biochemistry, Genetics and Molecular Biology, General Agricultural and Biological Sciences, General Medicine
Download fromView all 3 versions
PLoS ONE
Article . 2011
PLoS ONE
Article . 2011
Provider: Crossref
PLoS ONE
Article
Provider: UnpayWall
65 references, page 1 of 5

Simon, I, Barnett, J, Hannett, N, Harbison, CT, Rinaldi, NJ. Serial regulation of transcriptional regulators in the yeast cell cycle.. Cell. 2001; 106: 697-708 [OpenAIRE] [PubMed]

Vaughan, PS, van der Meijden, CM, Aziz, F, Harada, H, Taniguchi, T. Cell cycle regulation of histone H4 gene transcription requires the oncogenic factor IRF-2.. J Biol Chem. 1998; 273: 194-199 [PubMed]

Harris, ME, Bohni, R, Schneiderman, MH, Ramamurthy, L, Schumperli, D. Regulation of histone mRNA in the unperturbed cell cycle: evidence suggesting control at two posttranscriptional steps.. Mol Cell Biol. 1991; 11: 2416-2424 [OpenAIRE] [PubMed]

Van Den Abbeele, J, Claes, Y, van Bockstaele, D, Le Ray, D, Coosemans, M. Trypanosoma brucei spp. development in the tsetse fly: characterization of the post-mesocyclic stages in the foregut and proboscis.. Parasitology. 1999; 118 (Pt 5): 469-478 [PubMed]

Clayton, CE. Life without transcriptional control? From fly to man and back again.. Embo J. 2002; 21: 1881-1888 [OpenAIRE] [PubMed]

Kabani, S, Fenn, K, Ross, A, Ivens, A, Smith, TK. Genome-wide expression profiling of in vivo-derived bloodstream parasite stages and dynamic analysis of mRNA alterations during synchronous differentiation in Trypanosoma brucei.. BMC Genomics. 2009; 10: 427 [OpenAIRE] [PubMed]

Queiroz, R, Benz, C, Fellenberg, K, Hoheisel, JD, Clayton, C. Transcriptome analysis of differentiating trypanosomes reveals the existence of multiple post-transcriptional regulons.. BMC Genomics. 2009; 10: 495 [OpenAIRE] [PubMed]

Akopyants, NS, Matlib, RS, Bukanova, EN, Smeds, MR, Brownstein, BH. Expression profiling using random genomic DNA microarrays identifies differentially expressed genes associated with three major developmental stages of the protozoan parasite Leishmania major.. Mol Biochem Parasitol. 2004; 136: 71-86 [OpenAIRE] [PubMed]

McKean, PG. Coordination of cell cycle and cytokinesis in Trypanosoma brucei.. Curr Opin Microbiol. 2003; 6: 600-607 [PubMed]

Ho, HH, He, CY, de Graffenried, CL, Murrells, LJ, Warren, G. Ordered assembly of the duplicating Golgi in Trypanosoma brucei.. Proc Natl Acad Sci U S A. 2006; 103: 7676-7681 [OpenAIRE] [PubMed]

Hammarton, TC. Cell cycle regulation in Trypanosoma brucei.. Mol Biochem Parasitol. 2007; 153: 1-8 [OpenAIRE] [PubMed]

Pasion, SG, Hines, JC, Ou, X, Mahmood, R, Ray, DS. Sequences within the 5′ untranslated region regulate the levels of a kinetoplast DNA topoisomerase mRNA during the cell cycle.. Mol Cell Biol. 1996; 16: 6724-6735 [OpenAIRE] [PubMed]

Mahmood, R, Mittra, B, Hines, JC, Ray, DS. Characterization of the Crithidia fasciculata mRNA cycling sequence binding proteins.. Mol Cell Biol. 2001; 21: 4453-4459 [OpenAIRE] [PubMed]

Mittra, B, Sinha, KM, Hines, JC, Ray, DS. Presence of multiple mRNA cycling sequence element-binding proteins in Crithidia fasciculata.. J Biol Chem. 2003; 278: 26564-26571 [OpenAIRE] [PubMed]

Mittra, B, Ray, DS. Presence of a poly(A) binding protein and two proteins with cell cycle-dependent phosphorylation in Crithidia fasciculata mRNA cycling sequence binding protein II.. Eukaryot Cell. 2004; 3: 1185-1197 [OpenAIRE] [PubMed]

65 references, page 1 of 5
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