research data . Dataset . 2019

Allele-specific regulation of FGFR2 expression is cell type-dependent and may increase breast cancer risk through a paracrine stimulus involving FGF10

Huijts, Petra; Dongen, Minka Van; Goeij, Moniek De; Moolenbroek, Adrian Van; Blanken, Freek; Vreeswijk, Maaike; Kruijf, Esther De; Mesker, Wilma; Zwet, Erik Van; Tollenaar, Rob; ...
  • Published: 17 Sep 2019
  • Publisher: figshare
Abstract
Abstract Introduction SNPs rs2981582 and rs2981578, located in a linkage disequilibrium block (LD block) within intron 2 of the fibroblast growth factor receptor 2 gene (FGFR2), are associated with a mildly increased breast cancer risk. Allele-specific regulation of FGFR2 mRNA expression has been reported previously, but the molecular basis for the association of these variants with breast cancer has remained elusive to date. Methods mRNA levels of FGFR2 and three fibroblast growth factor genes (FGFs) were measured in primary fibroblast and epithelial cell cultures from 98 breast cancer patients and correlated to their rs2981578 genotype. The phosphorylation lev...
Subjects
Medical Subject Headings: integumentary systemstomatognathic diseasesembryonic structuresmusculoskeletal diseases
free text keywords: Space Science, Medicine, Cell Biology, Genetics, Molecular Biology, Developmental Biology, Cancer, Plant Biology, Computational Biology
Download fromView all 2 versions
figshare
Dataset . 2019
Provider: Datacite
figshare
Dataset . 2019
Provider: Datacite
Abstract
Abstract Introduction SNPs rs2981582 and rs2981578, located in a linkage disequilibrium block (LD block) within intron 2 of the fibroblast growth factor receptor 2 gene (FGFR2), are associated with a mildly increased breast cancer risk. Allele-specific regulation of FGFR2 mRNA expression has been reported previously, but the molecular basis for the association of these variants with breast cancer has remained elusive to date. Methods mRNA levels of FGFR2 and three fibroblast growth factor genes (FGFs) were measured in primary fibroblast and epithelial cell cultures from 98 breast cancer patients and correlated to their rs2981578 genotype. The phosphorylation lev...
Subjects
Medical Subject Headings: integumentary systemstomatognathic diseasesembryonic structuresmusculoskeletal diseases
free text keywords: Space Science, Medicine, Cell Biology, Genetics, Molecular Biology, Developmental Biology, Cancer, Plant Biology, Computational Biology
Download fromView all 2 versions
figshare
Dataset . 2019
Provider: Datacite
figshare
Dataset . 2019
Provider: Datacite
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