publication . Other literature type . Article . 2003

TREMs in the immune system and beyond

Marco Colonna;
  • Published: 01 Jun 2003
  • Publisher: Springer Science and Business Media LLC
Abstract
Triggering receptors expressed by myeloid cells (TREMs) belong to a rapidly expanding family of receptors that include activating and inhibitory isoforms encoded by a gene cluster linked to the MHC. TREM1 and TREM2 activate myeloid cells by signalling through the adaptor protein DAP12. TREM1 triggers phagocyte secretion of pro-inflammatory chemokines and cytokines, amplifying the inflammation that is induced by bacteria and fungi. TREM2 activates monocyte-derived dendritic cells and regulates osteoclast development. Remarkably, TREM2 deficiency leads to a severe disease that is characterized by bone cysts and demyelination of the central nervous system, which re...
Subjects
free text keywords: Immunology, TREM2, Major histocompatibility complex, biology.protein, biology, Receptor, Chemokine, Cell biology, Phagocyte, medicine.anatomical_structure, medicine, Inflammation, medicine.symptom, Immune system, Signal transducing adaptor protein, Cancer research
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