publication . Article . Other literature type . 2004

Topical Vascular Endothelial Growth Factor Accelerates Diabetic Wound Healing through Increased Angiogenesis and by Mobilizing and Recruiting Bone Marrow-Derived Cells

Galiano, Robert D.; Tepper, Oren M.; Pelo, Catherine R.; Bhatt, Kirit A.; Callaghan, Matthew; Bastidas, Nicholas; Bunting, Stuart; Steinmetz, Hope G.; Gurtner, Geoffrey C.;
Open Access
  • Published: 01 Jun 2004 Journal: The American Journal of Pathology, volume 164, pages 1,935-1,947 (issn: 0002-9440, Copyright policy)
  • Publisher: Elsevier BV
Abstract
Diminished production of vascular endothelial growth factor (VEGF) and decreased angiogenesis are thought to contribute to impaired tissue repair in diabetic patients. We examined whether recombinant human VEGF165 protein would reverse the impaired wound healing phenotype in genetically diabetic mice. Paired full-thickness skin wounds on the dorsum of db/db mice received 20 μg of VEGF every other day for five doses to one wound and vehicle (phosphate-buffered saline) to the other. We demonstrate significantly accelerated repair in VEGF-treated wounds with an average time to resurfacing of 12 days versus 25 days in untreated mice. VEGF-treated wounds were charact...
Subjects
free text keywords: Pathology and Forensic Medicine, Granulation tissue, medicine.anatomical_structure, medicine, Vascular endothelial growth factor, chemistry.chemical_compound, chemistry, Bone marrow, Neovascularization, medicine.symptom, Vascular endothelial growth factor A, Angiogenesis, Population, education.field_of_study, education, Wound healing, business.industry, business, Immunology, Regular Articles
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Abstract
Diminished production of vascular endothelial growth factor (VEGF) and decreased angiogenesis are thought to contribute to impaired tissue repair in diabetic patients. We examined whether recombinant human VEGF165 protein would reverse the impaired wound healing phenotype in genetically diabetic mice. Paired full-thickness skin wounds on the dorsum of db/db mice received 20 μg of VEGF every other day for five doses to one wound and vehicle (phosphate-buffered saline) to the other. We demonstrate significantly accelerated repair in VEGF-treated wounds with an average time to resurfacing of 12 days versus 25 days in untreated mice. VEGF-treated wounds were charact...
Subjects
free text keywords: Pathology and Forensic Medicine, Granulation tissue, medicine.anatomical_structure, medicine, Vascular endothelial growth factor, chemistry.chemical_compound, chemistry, Bone marrow, Neovascularization, medicine.symptom, Vascular endothelial growth factor A, Angiogenesis, Population, education.field_of_study, education, Wound healing, business.industry, business, Immunology, Regular Articles
Related Organizations
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publication . Article . Other literature type . 2004

Topical Vascular Endothelial Growth Factor Accelerates Diabetic Wound Healing through Increased Angiogenesis and by Mobilizing and Recruiting Bone Marrow-Derived Cells

Galiano, Robert D.; Tepper, Oren M.; Pelo, Catherine R.; Bhatt, Kirit A.; Callaghan, Matthew; Bastidas, Nicholas; Bunting, Stuart; Steinmetz, Hope G.; Gurtner, Geoffrey C.;