publication . Article . Other literature type . 2008

Stem Cells and Niches: Mechanisms That Promote Stem Cell Maintenance throughout Life

Sean Morrison;
Open Access
  • Published: 01 Feb 2008 Journal: Cell, volume 132, issue 4, pages 598-611 (issn: 0092-8674, Copyright policy)
  • Publisher: Elsevier BV
Abstract
Niches are local tissue microenvironments that maintain and regulate stem cells. Long-predicted from mammalian studies, these structures have recently been characterized within several invertebrate tissues using methods that reliably identify individual stem cells and their functional requirements. Although, similar single-cell resolution has not usually been achieved in mammalian tissues, principles likely to govern the behavior of niches in diverse organisms are beginning to emerge and considerable progress has been made elucidating the microenvironmental mechanisms that promote stem cell maintenance. These mechanisms may not only guide tissue homeostasis but ...
Subjects
free text keywords: Biochemistry, Genetics and Molecular Biology(all), Article, General Biochemistry, Genetics and Molecular Biology
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