publication . Article . Other literature type . 2006

Small-world networks and disturbed functional connectivity in schizophrenia

Michael Breakspear; Michael Breakspear; P. Bitsios; Ellie Pachou; Michael Vourkas; Sifis Micheloyannis; Sifis Micheloyannis; Cornelis J. Stam; Sophia Erimaki; M. Zervakis;
Restricted English
  • Published: 01 Oct 2006 Journal: Schizophrenia Research, volume 87, issue 1-3, pages 60-6 (issn: 0920-9964, Copyright policy)
  • Country: Netherlands
Abstract
Disturbances in "functional connectivity" have been proposed as a major pathophysiological mechanism for schizophrenia, and in particular, for cognitive disorganization. Detection and estimation of these disturbances would be of clinical interest. Here we characterize the spatial pattern of functional connectivity by computing the "synchronization likelihood" (SL) of EEG at rest and during performance of a 2Back working memory task using letters of the alphabet presented on a PC screen in subjects with schizophrenia and healthy controls. The spatial patterns of functional connectivity were then characterized with graph theoretical measures to test whether a disr...
Subjects
Medical Subject Headings: behavioral disciplines and activities
free text keywords: Adult, Cognition Disorders/diagnosis, Diagnostic and Statistical Manual of Mental Disorders, Female, Humans, Male, Memory Disorders/diagnosis, Nerve Net/physiopathology, Neuropsychological Tests, Schizophrenia/diagnosis, Severity of Illness Index, Schizophrenia, medicine.disease, medicine, Working memory, Cognition, Nerve net, medicine.anatomical_structure, Psychology, Electroencephalography, medicine.diagnostic_test, Mental illness, Neuroscience, Small-world network, Psychosis
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