publication . Article . Other literature type . 1989

Human interleukin-5 (IL-5) regulates the production of eosinophils in human bone marrow cultures: comparison and interaction with IL-1, IL-3, IL-6, and GMCSF.

Clutterbuck, EJ; Hirst, EM; Sanderson, CJ;
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  • Published: 01 May 1989 Journal: Blood, volume 73, pages 1,504-1,512 (issn: 0006-4971, eissn: 1528-0020, Copyright policy)
  • Publisher: American Society of Hematology
<jats:title>Abstract</jats:title> <jats:p>Recombinant human interleukin-5 (rhIL-5), in either liquid or semi- solid cultures, selectively induced eosinophil production from normal human bone marrow, with no activity on other cell lineages. The time course of eosinophil production induced by murine IL-5, rhIL-3, and rh granulocyte-macrophage colony stimulating factor (GMCSF) was similar to rhIL-5. The rate of eosinophil maturation in vitro was independent of the stimulating cytokine, mature eosinophils being produced after 4 to 5 weeks in liquid culture with each of these cytokines. The eosinophils produced in response to each cytokine were morphologically indist...
free text keywords: Immunology, Cell Biology, Biochemistry, Hematology
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Other literature type . 1989
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Article . 1989
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