publication . Other literature type . Article . 2000

Circadian clocks limited by noise.

Naama Barkai; Stanislas Leibler;
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  • Published: 01 Jan 2000
  • Publisher: Springer Science and Business Media LLC
Abstract
Circadian rhythms, which provide internal daily periodicity, are used by a wide range of organisms to anticipate daily changes in the environment1. It seems that these organisms generate circadian periodicity by similar biochemical networks within a single cell2. A model based on the common features of these biochemical networks shows that a circadian network can oscillate reliably in the presence of stochastic biochemical noise and when cellular conditions are altered. We propose that the ability to resist such perturbations imposes strict constraints on the oscillation mechanisms underlying circadian periodicity in vivo.
Subjects
Medical Subject Headings: food and beverages
free text keywords: Multidisciplinary
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